Nucleic-acid therapy
Objectives: Evaluate the diverse mechanisms through which valproic acid exerts its therapeutic effects across various medical conditions
Aptamers are small oligonucleotide molecules made by the systematic evolution of ligands by exponential enrichment (SELEX)
Aptamers have gained an increasing role as the molecular recognition element (MRE) in diagnostic assay development, since their first conception thirty years ago
Aptamers are single-stranded nucleic acid molecules that can fold into complex threedimensional structures, forming binding pockets and clefts for the specific recognition and tight binding of any given molecular target
4
2018 Dec 19;29(12):4160-4167
Overall, the surface modification of macrophages with nucleic acid aptamers improved the tumor cell
10 They developed ssDNA aptamer MPT64-A1 against
et al
The aptamer against the virus works through three main mechanisms: it directly binds to the virus and inhibits its infectivity, binds molecules or receptors to inhibit virus infection, and binds to virus-infected cells
96 One variant of tissue-SELEX is the Morph-X-Select
Aptamer-based LFAs (ALFA) offers a more flexible design and the ability to detect a wider range of targets
A novel strategy to enhance the stability of DNA aptamers against nucleases is by capping at its one end (Shoji et al
This is first to report the successful isolation of PFAS binding ssDNA aptamers
Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable of binding non-covalently with high affinity and specificity to a target molecule