Methods: EURIDIS and ADONIS were double-blind, multinational, parallel-group trials
Dronedarone is a noniodinated benzofuran derivative, with a pharmacologic profile similar to amiodarone's but with different relative effects on individual ion channels
Amiodarone has been the drug of choice for AF but has several side effects like tremors, peripheral neuropathy, pulmonary inflammation, hypo/hyperthyroidism, and photosensitivity
There was a higher incidence of
Based upon the investigational clinical trials to Jul 24, 2023 · Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias
hrthm
7-10 Thus, compounds that are devoid of such effects but that Oct 11, 2022 · Dronedarone is a congener of amiodarone, with the omission of its iodine molecule, developed with the intention of reducing the likelihood of toxic side effects, and it is consequently a safer alternative to amiodarone and was also a popular choice in EAST-AFNET 4
Pacerone (amiodarone) Pacerone (amiodarone) is an alternative to Multaq for rhythm control in patients with concomitant congestive heart failure or left ventricular systolic dysfunction
The choice of Dec 30, 2011 · Dronedarone, like amiodarone, has effects on multiple cardiac ion channels and receptors
The incidence of the primary efficacy endpoint defined as first recurrence of AF or premature study drug discontinuation for intolerance or lack of Sep 21, 2023 · There is limited information on the optimal timing to switch from amiodarone to dronedarone
2 g/day (some patients respond to every 12-hour dosing)
Normally you would hold a drug for around 3 half-lives before initiating the new therapy