The author would urge caution and objective drug screening Bupropion 5-7 and naltrexone 8-10 used individually have shown some positive evidence of efficacy in clinical trials for the treatment of methamphetamine use disorder
Naltrexone is known to frequently cause stomach side effects like nausea and vomiting, stomach pain or cramping, and loss of appetite which could contribute to weight loss
Naltrexone may also curb hunger and food cravings
Bupropion is in a class of medications called antidepressants
Do not use naltrexone and bupropion combination if you are also using Zyban® to quit smoking or Aplenzin® or Wellbutrin® for depression, because they also
Naltrexone and Bupropion
Talk with the doctor
Bupropion is thought to work by
0- and 3
Contrave is an oral tablet that only comes in one dose: 8 mg of naltrexone and 90 mg of bupropion
More about Contrave (bupropion / naltrexone) Generic Status: Lower-cost generic is available
61% of reviewers reported a positive effect, while 21% reported a negative effect
Contrave ( naltrexone / bupropion) is a combination product used to promote and maintain weight loss in obese adults or overweight adults who have weight related medical problems
However, naltrexone isn’t typically prescribed on its own for this use
Bupropion is an antidepressant that helps to restore the balance of certain natural substances (dopamine, norepinephrine) in the Bupropion/naltrexone is a combination medication used for chronic weight management in overweight and obese adults, in addition to increased physical activity and a reduced-calorie diet
The efficacy and safety of this combination have been demonstrated in four 56-week, placebo Cardiovascular safety of naltrexone and bupropion therapy: Systematic review and meta-analyses
These active ingredients are also available separately as generic drugs
In previous clinical studies, however, both bupropion and naltrexone administered alone showed limited, inconsistent efficacy in treating methamphetamine use disorder
Overall, naltrexone is a safe and effective drug when used as prescribed
Bupropion is a dopamine and norepinephrine reuptake inhibitor that was first approved for the treatment of depression (4-6) and later for smoking cessation (7,8)
Talk with the doctor
Bupropion is metabolized to three active metabolites once in the body, each with varying durations of action