For the treatment of OCD, clomipramine was found to be more effective than sertraline, fluoxetine, and fluvoxamine in a meta-analysis
2 mg/day, amitriptyline, 122
The only FDA-approved use for clomipramine is to treat obsessive-compulsive disorder (OCD) in ages ten and older
In addition, summaries of product characteristics (SmPC) of nortriptyline, clomipramine, imipramine and amitriptyline were reviewed
3109/00207457909147672 Clomipramine is the most potent 5-HT reuptake blockade agent among the antidepressants
Background: Dose equivalence of antidepressants is critically important for clinical practice and for research
Conservative switching strategies involve gradually amitriptyline
5 (liquid) Nil
For example, in about half of 22 patients treated with a fluvoxamine-clomipramine combination, clomipramine levels were unacceptably high at 500-1,200 ng/mL, although serious side effects were few
follow up by GP, GP to consider HMR referral) stopped/ reduced with aim of stopping current medication e
Clomipramine (Anafranil) is a tricyclic antidepressant used to treat obsessive-compulsive disorder (OCD)
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA)
by 25 mg/day q4-7 days; Max: 3 mg/kg/day up to 100 mg/day in first 2wk and up to 200 mg/day maint
Most anxiolytics (‘sedatives’) will induce sleep when given at night and most hypnotics will sedate when given during the day
amitriptyline and clomipramine both increase serotonin levels
conivaptan will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism
The risk of withdrawal symptoms is increased if the antidepressant is stopped suddenly after regular administration for 8 weeks or more
The clinical efficacy of oral clomipramine and amitriptyline treatment (50--125 mg/day) was compared over a period of 2 months in 72 depressive patients visiting a psychiatric out-patient clinic
Amitriptyline, imipramine, clomipramine, dothiepin and doxepin are more potent CYP450 inhibitors and significantly inhibit CYP 2C19 and 1A2
Clomipramine hydrochloride capsules USP is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants
Clomipramine
2