Background
4 per 1000 person-years; adjusted
Administration of dabigatran 2 hours before verapamil completely avoided the interaction
Physiologically-based pharmacokinetic modeling to predict drug-drug interactions of dabigatran etexilate and rivaroxaban in the Chinese older adults (DABE) and 21-60% (rivaroxaban), respectively, during NOACs monotherapy
There's not enough information to say that other herbal remedies and supplements are safe to take with dabigatran
Manufacturer advises use with caution or avoid
Direct oral anticoagulants (DOACs)—dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Savaysa), and betrixaban (Bevyxxa) are anticoagulation pharmacotherapy used for the prevention of thrombosis in several cardiovascular contexts
Medscape - VTE prevention/treatment dosing for Pradaxa (dabigatran), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
accessory AV tracts
People taking dabigatran along with the antihypertensive medications verapamil or diltiazem suffered more bleeds than peers whose dabigatran use was accompanied by amlodipine (adjusted HR 1
Discussion
Adult 18–74 years
Oral bioavailability of dabigatran etexilate (Pradaxa®) after co-medication with verapamil in healthy subjects
Management options
Prophylaxis of venous thromboembolic events following knee replacement surgery
A semi-mechanistic absorption model to evaluate drug–drug interaction
Several factors affected the interaction: (i) the dosing interval between the two drugs, such that the maximum increase in dabigatran exposure occurred when verapamil was given 1 h before DE, whereas there was virtually no
Discussion
The bioavailability of dabigatran is increased when co-administered with a P-gp inhibitor, such as verapamil