BHT is induced by imperfect desquamation of the Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer
The exact method by which linezolid causes
A sore mouth happens because some cancer drugs kill not only the quickly dividing cancer cells but also the cells that make up the lining of your mouth
Mar 1, 2006 · Defervescence occurred within 3 days in 21 (30
Dec 27, 2021 · Linezolid induced black hairy tongue is a benign and self-limiting condition
Coated tongue describes any area of the tongue with a coating on it
In 3 out 4 drugs is Introduction Black hairy tongue (BHT), also called "lingua villosa nigra", is a benign condition characterized by elongation and hyperplasia of the filiform papillae into "hair-like" prolongations and the appearance of a brown or black discoloration of the dorsal part of the tongue ( 1 )
However, the use of linezolid has been associated with rare adverse drug reactions (ADRs), one of which is the linezolid-associated black hairy tongue (BHT)
The severe dysbiosis of oral bacterial communities was observed in all these patients
Case report Black tongue associated with linezolid Darkening of the tongue and oral mucosa is a reaction pattern that can be related to a number of physiologic, metabolic, and toxic disorders, and medications and exogenous substances
Linezolid is a synthetic antibiotic, belonging to oxazolidinones, with unique bacteriostatic activity against antibiotic-resistant Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci
" Coated tongue describes any area of the tongue with a coating on it
Here, we describe the case of an MDR-TB patient with a linezolid-induced back hairy tongue (BHT)
A 30-year-old female patient weighing 45 kg with proven MDR pulmonary TB was started on Inj kanamycin, cycloserine, ethionamide, moxifloxacin, PAS and linezolid
5 However, rare adverse events with the increased long-term use of linezolid for MDR-TB may raise concerns
Several factors have been implicated and included smoking or Figure 1: Open in new tab Download slide ( a) Hairy tongue during linezolid treatment; ( b) Normal tongue 3 weeks after discontinuing Linezolid; ( c) Results of the Naranjo Adverse Drug Reaction Probability Scale
Tongue discoloration occurs in nearly two week or long-term use of linezolid and can be resolved 2-3 weeks after linezolid discontinuation, 6 but the BHT may recur after reintroduction of linezolid
It is indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections, including infections complicated by bacteremia
shiny, swollen, or red gums
nausea or vomiting
Under normal circumstances, the tongue is a pink, muscular organ located within the oral cavity proper
The tongue is a mobile, muscular organ that lies within the mouth and partly extends into the upper throat
Antibiotics such as linezolid will not work for colds, flu, and other viral infections
Red or white patches on your tongue or thickened areas that don't go away may be a sign of tongue cancer
1% in patients with cutaneous psoriasis [ 2, 9 ]
It binds to the 50S ribosomal subunits of bacteria, resulting in inhibition of mitochondrial protein synthesis
Synonyms: none
Oral mucositis is a common complication of radiotherapy to the head and neck region, chemotherapy and the combination of the two such as seen in conditioning regiments for homologous stem cell transplantation (HSCT)
Patients receiving radiation, especially in the cases of head and neck Linezolid-induced black hairy tongue has been rarely reported
The hard palate can be involved which is an unusual location for OLP, however similar to OLP the ventral tongue and floor of mouth is uncommon location
doi: 10
Total treatment duration is 3 to 4 weeks (in the absence of osteomyelitis); prolonged use of linezolid may be limited by toxicity (Goldenberg 2019; IDSA [Liu 2011])
Data on oral mucositis were available for 371 subjects at baseline and 211 subjects at 6 months
The oral cavity provides a unique ecological site that harbors a dynamic microbiota
They are innervated by the hypoglossal nerve - with the exception of the palatoglossus, which is innervated by the vagus nerve
Soreness or pain in the mouth or throat
30 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes
The colour of discoloration can range from black to brown, green, or blue 5
Mucositis is usually associated with high-dose chemotherapy, radiotherapy and, more recently, molecular targeted therapy
-Soreness or pain in the mouth or throat
Linezolid is a synthetic oxazolidinone antibiotic, active against gram-positive bacteria
Oral Thrush
Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and Linezolid tablets are an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram Superficial tooth discoloration and tongue discoloration have been reported with the use of linezolid
5 during radiation fractions 15 The tongue is a muscular organ of the oral cavity and is an accessory digestive organ in the digestive system
Mucositis results from the effects of radiation on DNA replication and proliferation of rapidly dividing basal cells of the tongue epithelium
Oral thrush causes creamy white lesions, usually on your tongue or inner cheeks
Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia
Common adverse events of long-term linezolid use include bone marrow sup- pression and neuropathies
Thirteen days after intake of linezolid, asymptomatic black tongue was observed , and tongue swab detected Escherichia coli
An extensive literature search revealed no case reports of BHT in Bangladesh due to linezolid drug treatment management
These drugs can cause several adverse
Citations: 1 Sections PDF Tools Share Abstract Linezolid therapy is known to cause black hairy tongue, which is benign and reversible
It’s a common side effect of cancer treatments involving
The incidence of black hairy tongue in patients receiving linezolid was 0
The
Oral mucositis is a severely debilitating condition characterized by erythema, edema, and ulcerations of the oral mucosa
Amalgam restorations can cause lichenoid lesions and are found on the buccal mucosa or the tongue in direct contact with the amalgam
It is a nonhematologic complication of cytotoxic chemotherapy and radiotherapy and reduces the quality of life
To avoid the occurrence of the condition it is always advised to maintain a good oral hygiene and by avoiding the concomitant risk factors like smoking and rinsing the mouth with warm water after consumption of coffee, green tea or other colored beverages
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The tongue has a very rich neurovascular supply, and its importance in humans is tightly connected to the digestive system and speech
Total treatment duration is 3 to 4 weeks (in the absence of osteomyelitis); prolonged use of linezolid may be limited by toxicity (Goldenberg 2019; IDSA [Liu 2011])
Data on oral mucositis were available for 371 subjects at baseline and 211 subjects at 6 months
Extrinsic Muscles
The oral cavity provides a unique ecological site that harbors a dynamic microbiota
Lichen planus (LP) is a dermatological condition that affects the skin and/or mucous membranes, frequently encountered in middle age women, but also in males
Black hairy tongue (BHT) is a very rare side-effect of linezolid which presents as hypertrophy and discoloration of the filiform papillae of the tongue 4
Linezolid induced black hairy tongue is a rare benign reversible side effect of linezolid therapy
However, the degree of discoloration was not as severe as in the first episode and she does not complain of any related symptoms
Soft, whitish patches or pus in the mouth or on the tongue
Mucositis is usually associated with high-dose chemotherapy, radiotherapy and, more recently, molecular targeted therapy
The symptoms started during a 10-week treatment with Linezolid for post-knee arthroplasty complicated with Methicillin-resistant Staphylococcus aureus infection