In the other primary route the inactive lactone prodrug is hydrolysed to the pharmacologically active simvastatin acid by Aug 17, 2023 · Zocor may cause serious side effects including: loss of appetite, upper-right side stomach pain, tiredness, itching, dark urine, clay-colored stool, and
When simvastatin is taken 24 hours after ingestion of "high-dose" grapefruit juice, the effect of grapefruit juice on the AUC of simvastatin is only about 10% of the effect observed during concomitant intake of grapefruit juice and simvastatin
You should not drink grapefruit juice with
Eating grapefruit may negatively interact with certain statin drugs, such as atorvastatin, lovastatin, and simvastatin
The cited studies also used high-dose statins (80 mg of lovastatin, 60 mg
Levels of simvastatin and lovastatin are 260 percent higher if taken with
Analyse: Grapefruitsaft und Simvastatin sind keine guten Partner, daher
A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken)
Diese Kombination kann zu einer Verzögerung des Stoffwechsels, Tachykardie, einem erhöhten Blutdruck und bis zum Tod führen
Simvastatin does not upset your stomach, so you can take it with or without food
Lue tämä pakkausseloste huolellisesti ennen kuin aloitat tämän lääkkeen ottamisen, sillä se sisältää sinulle tärkeitä tietoja
[4] It is also used to decrease the risk of heart problems in those at high risk
Simvastatin with grapefruit juice at high volume (400 mL, 3 times/d for 3 d) had an AUC that was 700% of that for water; at a more usual amount of juice (200 mL, once daily for 3 d), the AUC was 330% of that with water
Fluvastatin ist ein CYP2C9-Substrat, dessen Abbau durch Einnahme anderer CYP2C9
Nicotinic acid
Both Simvastatin and Nicotinic acid can increase the risk of hepatotoxicity
Children younger than 10
Simvastatin, an HMG-CoA reductase inhibitor, is widely used in the treatment of hypercholesterolaemia
0-fold and 4
After an interval of 3 or 7 days between ingestion of grapefruit juice and Grapefruit juice effects
Monitor INR We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins
Simvastatin (Zocor) can also raise your "good" cholesterol (called high-density lipoprotein, or HDL) levels and liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)