Response to dapsone as per international working group definitions, time to response along with side-effects were noted
Dosage should be reduced to a minimum maintenance level as soon as possible
Usual Pediatric Dose for Acne Rifampin: Plasma concentration reduced as Dapsone is a substrate of cytochrome P-450 3A4
82 mg/L
6 mg per pound) of body weight once a day
Dapsone
59 (range 1–2
Merative, Micromedex Dapsone , a sulfone, belongs to the family of medicines called anti-infectives
Overall response was seen in 21/29 (72%): Complete Response in 7/29 (24%), Partial Response in 14/29
If full control is not achieved within the
A prolonged exposure of dapsone may be required for sustained response as the relapse rate ranges from 21 to 100% and less than 10% of the patients may continue to be
59 mg/kg/day (range 1-2
5 years) and average time before discontinuance is 29 months (range 6 months to 9 years)
(twice daily for 14 days) were compared to a single 100 mg oral dose of dapsone after a 14-day washout period
Statistical considerations For the retrospective portion of the study, the primary endpoint was time to the development of symptomatic methemoglobinemia
permitting many to reduce or eliminate the need for Dapsone; the average time for dosage reduction is 8 months with a range of 4 months to 2 1/2 years and for dosage elimination 29 months with a range of 6 months to 9 years
NHDP Recommendations: Paucibacillary (PB)/Tuberculoid (TT and BT): 10 to 20 mg/kg orally once a day PLUS dapsone Maximum dose: 600 mg/day Duration of therapy: 12 months, then discontinue Multibacillary (MB)/Lepromatous (LL, BL, BB): 10 to 20 mg/kg orally once a day PLUS dapsone and
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Oral dosage in adults and children weighing 40 kg (88 pounds) or more should have a single tablet of 800 mg of sulfamethoxazole and 160 mg of trimethoprim every 12 hours for 10 to 14 days
Safety and efficacy in pediatric patients have not been determined
Therefore, for this method, the weight of the child is considered in lbs not kilograms
Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia
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Do not start, stop, or change the dose of any drug your child takes without checking with the doctor
Age was factored into the dapsone dosing strategies; the results due to different strategies from the 2 groups are summarized in Table 4
Children younger than 10 should receive appropriately reduced dapsone dosage at 2 mg/kg body
shown a persistent response
One-fifth of the children relapsed on dapsone or after dis-continuation of dapsone
Peak serum concentrations are reached within 2 h – 8 h
If full control is not achieved within the range of 50-300 mg daily, higher doses may be tried