This activity describes the indications, actions, and contraindications of ketoconazole as a valuable agent in treating fungal infections
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The mother continued to breastfeed the infant during therapy
Since the medication is used to treat non-life threatening conditions (nail and scalp fungal infections), it is recommended that oral terbinafine be avoided during pregnancy
25 hours after the dose and the average milk level was 68 mcg/L
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Topical terbinafine: as less than 5% of the applied dose is absorbed through the skin, topical
The use of ketoconazole shampoo or topical use on the skin by the mother poses little or no risk to the breastfed infant
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Pediatric Use
For women who are breastfeeding: Ketoconazole passes into breast milk and may cause side effects in a child who’s breastfed
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Wait at least 2 hours after dose before taking antacids, anticholinergics, or H2 antagonists Common side effects of ketoconazole may include: nausea, diarrhea, stomach pain
You may report side effects to FDA at 1-800-FDA-1088
It’s available as an oral tablet, topical cream, topical foam, shampoo, and topical gel
Extent of oral absorption by the
22 ~g/ml was observed at 3
5 Because there is little published experience with ketoconazole or levoketoconazole during breastfeeding and its potential liver enzyme inhibition and liver toxicity, other agents are preferred
In general, for older and heavier babies, medications in their mother’s milk are less harmful
Penicillins, such as amoxicillin and ampicillin
Originally developed as an antifungal agent, ketoconazole
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The half-life in milk was about 30 hours
A pharmacokinetic model predicted a half-life in milk of 39 hours which is consistent with a THC clearance from
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It is in the same class of drugs as itraconazole , fluconazole , and miconazole (Micatin, Monistat)
This may cause enlarged breasts, not able to get an erection, or low sperm counts
According to Dr
Ketoconazole tablets have not been systematically studied in children of any age, and essentially no information is available on children under 2 years
His ground-breaking book is now in its 17th edition and is continuing to help mothers make the right decisions when taking