In some cases, these severe allergic reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), have happened with or without a rash
Some dosage forms listed on this page may not apply to the brand name Depakote
These are serious warnings from the Food and Drug Administration (FDA)
Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches
change in walking and balance
Talk to your healthcare provider about the risks and benefits of Depakote before you start it
The severity of hepatotoxicity can range from reversible hepatic dysfunction to irreversible liver failure
Both children and adults can be affected, even after several years of taking Depakote ER or another valproate medicine
It can also be used to prevent migraines and treat bipolar disorder
This may include the return of seizures, migraines, or bipolar symptoms like depression or mania
There have been rare reports of Fanconi's The rare events - identified early in the pandemic - included a higher risk of heart-related inflammation from mRNA shots made by Pfizer Inc, BioNTech SE, and Moderna Inc, and an increased Table 5: Adverse Reactions Reported by > 5% of Depakote-Treated Patients During Migraine Placebo-Controlled Trials with a Greater Incidence Than Patients Taking Placebo 1
Depakote and Depakote ER may cause pancreatitis ( inflammation of the pancreas)
This medicine is an anticonvulsant that works in the brain tissue to stop seizures
This medicine is an anticonvulsant that works in the brain tissue to stop seizures
If stomach upset occurs, you can take it with food
(1% to 10%): Abnormal gait, amnesia, catatonic reaction, convulsion, disturbance in attention, dysarthria, extrapyramidal disorder, hypertonia, hypokinesia, incoordination, The best-described adverse effects in the literature are represented by agranulocytosis, myocarditis, sedation, weight gain, hypotension, and drooling; nevertheless, there are other known adverse effects that psychiatrists should readily recognize and manage
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but severe cutaneous drug hypersensitivity reaction
DILI is commonly overlooked when investigating Allergic reactions can be severe and may require immediate intervention to prevent further complications
Most of the time, liver problems happened within the first 6 months after starting Depakote (divalproex sprinkle capsules)
Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs
Extrapyramidal side effects (EPS), commonly referred to as drug-induced movement disorders are among the most common adverse drug effects patients experience from dopamine-receptor blocking agents
Severe multiorgan reactions: Treatment with DEPAKOTE may cause severe multiorgan reactions that can be life-threatening or may lead to death
Divalproex sodium is used to treat certain types of seizures (epilepsy)
The incidence of DRESS is about one in 1,000 to one in 10,000 drug exposures ( 1 )
Rare cases of coma have occurred in patients receiving valproate alone or in conjunction with phenobarbital
Depakote may be used to treat certain types of seizure disorder, reduce mania in people with bipolar disorder, and as a preventive treatment for migraines
(divalproex sodium) Another potentially rare adverse reaction to Depakote is pancreatitis
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Precautions
Unlike Neurontin (generic name gabapentin Neuroleptic malignant syndrome (NMS) is a life-threatening syndrome associated with the use of dopamine-receptor antagonist medications or with the rapid withdrawal of dopaminergic medications
Depakote is known to interact with 740 drugs, out of which 21 drug interactions are major, 668 drug interactions are moderate, and 51 drug interactions are minor
Pharmacology, adverse reactions, warnings and side effects
Dizziness and tremors may also occur
Valproic acid may cause serious allergic reactions affecting multiple body
In patients taking Depakote, the most common side effects include:
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This includes signs that Depakote isn’t working as well as it should
Mitochondrial disorders are rare conditions caused by gene mutations affecting the mitochondria
Report pain in the abdomen, upset stomach, vomiting, or loss of appetite to the doctor
It was first described in 1952 after chlorpromazine-induced symptoms resembling Parkinson disease
Severe multiorgan reactions: Treatment with DEPAKOTE may cause severe multiorgan reactions that can be life-threatening or may lead to death
The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment
Depakote may be used to treat certain types of seizure disorder, reduce mania in people with bipolar disorder, and as a preventive treatment for migraines
Adults, aged 18 and above, can take it to prevent migraine
A very serious allergic reaction to this drug is rare Severe multiorgan reactions: Treatment with DEPAKOTE may cause severe multiorgan reactions that can be life-threatening or may lead to death
VFS consists of a pruritic, erythematous rash to the face, neck, and upper torso, which may also involve the extremities to a lesser degree
It was first approved by the FDA in 1983 and is used primarily to treat certain types of seizures and bipolar disorder
A very serious allergic reaction to this drug is rare