Chloramphenicol is an antibiotic Overview of Antibacterial Drugs that is primarily bacteriostatic
In the past it was in common use due to its broad spectrum of activity against many Gram
Technically, “antibiotic” refers only to antimicrobials derived from bacteria or molds but is often (including in THE MANUAL) used synonymously with “antibacterial
Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol
Aminoglycosides, tetracycline, chloramphenicol, erythromycin, and clindamycin all interfere with ribosome function
Nowadays numerous different classes of antimicrobial agents are known and they are classified based on their mechanisms of action (Neu, 1992)
Chloramphenicol can be isolated from Streptomyces venezuelae in soil
The discovery of the first selective antimicrobial agent approximately four decades ago was a major milestone in the history of medicine and human health
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Our interaction with microorganisms is constant and ever changing, and it is this dynamic Antimicrobial resistance is a major threat to human health
disrupts cell membranes D
Most antimicrobial agents used in clinical practice are (or derive from) products naturally found in the environment (mostly soil)
The bacteriological aetiology of dental caries promotes the use of antibiotics or antimicrobial agents to prevent this type of oral infectious disease
Those that are monitored include the aminoglycosides (gentamicin, tobramycin, and amikacin), chloramphenicol, and in some cases, vancomycin
In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and studied
Clindamycin is effective in the treatment of most infections involving anaerobes and gram-positive cocci, but emerging resistance has become a problem in some clinical settings
Bactericidal antibiotics kill bacteria; bacteriostatic antibiotics inhibit their growth or reproduction
Antibiotic resistance of the causative agents of infectious diseases is a global problem in biology and medicine [1, 2]
Historically, chloramphenicol, Study characteristics that were abstracted included first author, publication year, normally sterile specimen type, and country of specimen collection
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