1 [7], consists of the pharmacophore and its moiety containing a ring system with different substituents
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Only lovastatin and
Chemically, cholesterol is an organic compound belonging to the steroid family; its molecular formula is C 27
This means it has 27 atoms of carbon, 46 of hydrogen, and one of oxygen
3 kg, 10
Parke-Davis was not the first drug company to put a statin on the market (Merck was), but it was the one to do it the best, with Lipitor (atorva statin)
It has a role as a human metabolite, a
Join us to hear from Jennifer Love of the University of Calgary! Abstract: The conversion of readily-available raw materials into more valuable products is crucial for
Serious side effects of Lipitor that have been reported include: irregular results of liver function tests, which could be a sign of liver damage
60 events in the LIPITOR group)] with a relative risk reduction of 36% [(based on incidences of 1
Atorvastatin 6 (Figure 7) is a synthetic statin that contains an unusual penta-substituted pyrrole ring in place of the hexahydronaphthalene found in the early statins
Atorvastatin, cerivastatin (withdrawn from clinical use in 2001), fluvastatin Generally, the chemical structures of statins, as shown in Figure 1, are divided into 2 segments (7): i
When Parke-Davis Pharmaceuticals in Ann Arbor, Michigan, began to look for its own statin in 1982, it was late in the game
Bruce D
The solubilities of cholesterol in methanol, anisole, acetic acid, ethyl acetate, heptane, methyl isobutyl ketone (MIBK), and mixed solvent (ethanol–MIBK) are determined in the temperature range of 283
Its total synthesis was one of the most remarkable achievements of 20th century Chemistry, accomplished almost simultaneously by Robinson in Oxford
Statins reduce low-density lipid-cholesterol (LDL-C) and increase high-density lipid-cholesterol levels (HDL-C) []
It’s a white, crystalline substance that’s odourless and tasteless
Lovastatin, pravastatin and simvastatin are derived from fungal metabolites and have elimination half-lives of 1–3 h
Cholesterol is a waxy, fat-like substance that your body needs for good health, but in the right amounts
muscle pain, tenderness, or weakness