These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and
This
In patients with severe renal impairment, half-lives and serum concentrations of fibrates can be increased [Miller and Spence, 1998] and drug interactions between fibrates and statins may be more likely
Gemfibrozil plus pravastatin (Pravachol) can increase blood-statin concentrations by more than 200%
Gemfibrozil is used to lower Gemfibrozil is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and triglycerides (other fatty substances) in the blood in certain people with very high triglycerides who are at risk of pancreatic disease (conditions affecting the pancreas, a gland that produces fluid to break down food and hormones to control
0000000000000456 November 22, 2016 e469 CLI n ICAL S t A te M ent S A n D GUID e LI ne S affordability may often dictate which medications may be prescribed
An in vitro study was carried out in order to examine the metabolic basis of the interaction between fibrates and statins
The risk of
These findings suggest a statin-specific interaction with gemfibrozil that may not be a "class effect
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Two fibrates that interact with rosuvastatin are gemfibrozil (Lopid) and fenofibrate (Tricor)
Atorvastatin has an average rating of 4
Fibrates are another group of medications that treat high cholesterol (and high triglycerides)
4 Gemfibrozil, whose interaction with simvastatin is primarily dependent on OATP inhibition and does not inhibit CYP3A4, produces a similar increase in simvastatin concentrations and an increased risk of myopathy
Common side effects of gemfibrozil include gastrointestinal upset, diarrhea, constipation and fatigue
Pharmacokinetic data on the interactions between statins and fibrates suggest that gemfibrozil inhibits statin glucuronidation and its hepatic metabolism, inducing therefore higher statin concentrations, whereas other fibrates, such as fenofibrate, have a relatively low potential for interaction with statin metabolism
[2] It is unclear if it changes the risk of heart disease
Side effects, drug interactions, warnings and precautions, and efficacy during pregnancy information should be reviewed prior to taking this medication