In pharmacokinetic terms the lipophilic beta-blockers have been shown, both in animals and man, to readily cross the blood-brain barrier in contrast to hydrophilic beta-blockers
This represented an alternative and underdosed form of metoprolol, differing from the metoprolol succinate at 200 mg daily used in the MERIT-HF trial, which demonstrated a reduction in all-cause mortality
Design Randomised, double blind, crossover study comparing the effect of atenolol (50 mg once daily) with metoprolol CR (100 mg once daily) with
7 Furthermore, the lipophilic type have been associated with daytime somnolence, insomnia, nightmares
Propranolol is the most lipophilic of the beta-blockers, and thus its concentration in the brain is higher than that of other drugs used for the same indication [2]
2
Metoprolol, a lipophilic beta 1-specific adrenoceptor antagonist, was specifically chosen because the patient was tachycardic but normotensive
Metoprolol is also used to lower your risk of death or needing to be hospitalized for heart failure
Metoprolol is mainly lipophilic, and its distribution is typical of a basic lipophilic drug
Initial treatment of bradycardia and hypotension included The lipophilic beta(1)-selective beta-blocker metoprolol was found to prevent cardiac dysfunction and remodelling and extend the survival of knock-in mice