You can reverse Warfarin acutely by giving either FFP (which contains all these factors Anticoagulant reversal agents are required when anticoagulant therapy needs to be reversed or neutralized in situations when there are bleeding complications, an overdose of anticoagulant therapy or unplanned surgery is required
half-life, duration of action)
1 The incidence of bleeding while on warfarin has been estimated at 15–20% per year, with life
Andexanet alfa and idarucizumab are specific reversal agents for
It is
An update of consensus guidelines for warfarin reversal
Anticoagulants / adverse
Idarucizumab is a humanized monoclonal antidabigatran antibody fragment approved for reversing dabigatran-associated bleeding
5 Hold dose until INR decreased 4
Idarucizumab is a humanized monoclonal antibody fragment developed as a specific reversal agent for dabigatran
g
Clinical Considerations: 1 mg of protamine
Vitamin K Antagonist (i
REVERSAL/HEMOSTASIS* Vitamin K Antagonists (warfarin) Reversal Strategy Dosage 4F-PCC† Note regarding vitamin K: When PCCs are used to reverse VKAs, vitamin K should also always be given
Patient demographics (age, gender, race), Glasgow Coma Scale (GCS), Injury Severity Score (ISS), AIS-H, findings on head CT scan (subdural hematoma, epidural hematoma, intraparenchymal hemorrhage
Argatroban half-life 40 - 50 minutes
Drug: Warfarin (Coumadin) Reversal: Prothrombin complex concentrates (PCCs), Vitamin K, fresh frozen plasma (FFP) for coagulation factor replacement
Specific reversal agents for non–vitamin K antagonist oral anticoagulants are lacking
Oral administration of vitamin K has emerged as the preferred route for non-emergent reversal of warfarin-induced excessive anticoagulation in the absence of significant bleeding
All patients who are actively bleeding should receive 5-10mg of IV vitamin K by slow infusion