The major metabolite is the O-alkylglucuronide, with smaller amounts of the O- phenylglucuronide and N-glucuronide being formed
Appropriate laboratory testing should be done at the first symptom/sign of liver dysfunction (e
Labetalol is metabolized by the liver resulting in an inactive glucuronide conjugate
Labetalol is one of the most commonly used anti-hypertensives
Labetalol hepatotoxicity is thought to be idiosyncratic, although the
If it continues for a long time, the heart and arteries may not function properly
Therapy with labetalol should be administered cautiously in patients with a current or past history of liver disease
Labetalol is a combined alpha- and beta-adenoceptor blocking agent for oral and intravenous use in the treatment of hypertension
Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm Abstract
Sometimes, this has been deadly
Labetalol hydrochloride is an adrenergic receptor blocking agent that has both selective alpha 1 - and nonselective beta-adrenergic receptor blocking actions in a single substance
Labetalol is an antihypertensive agent with both alpha- and beta-adrenergic receptor blocking activity
In Clark's If the patient has laboratory evidence of liver injury or jaundice, labetalol should be stopped and not restarted
Check with your doctor right away if you are having chest pain or discomfort 2
As the prescription of Subsequent, liver biopsy demonstrated acute hepatocellular injury without eosinophils, cholestasis, steatosis or fibrosis
liver problems --loss of appetite, stomach pain (upper right side), flu-like symptoms, itching, dark urine, jaundice (yellowing of the skin or eyes)
Cardiac Failure
Also tell your doctor if you Labetalol hydrochloride is an adrenergic receptor blocking agent that has both selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance