In 2014, Shalev’s UAB research lab discovered that verapamil completely reversed Type 1 diabetes in animal models and sought to test the effects of the drug in
A study in Nature on type 2 diabetes 2 is an example of the power of using a database that includes diverse genomes, Ramirez says
Citation: Study finds diabetes medicine behind false positive urine test (2024, February 27) Besides Shalev’s adult study, a recent independent study of children with Type 1 diabetes has also confirmed that verapamil preserves beta cell function
Study finds youth-onset diabetes is a genetically distinct form of the disorder
No C-peptide Effect of Tight Glycemic Control: " A Tough Pill " Abstract
, 2017), and the evidence to date suggests it is likely that verapamil preserves beta cell function in diabetes models by repressing thioredoxin-interacting protein (TXNIP) expression and thus protecting
The letter by Dr Hsu and colleagues raises several
The findings, published in Diabetes Research and Clinical Practice, follow work that showed verapamil reversed diabetes in mice with type 1 diabetes (T1D), and create anticipation for results of a Drug: Verapamil SR 120 mg Drug: Placebo
Verapamil is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension)
In the Diabetes study, Xu, Shalev and colleagues did a global proteomics study analysis of serum samples from Shalev's adult study both at baseline and at one year of receiving verapamil or a In another study of patients with no prior diabetes, oral verapamil use was associated with a lower incidence of type 2 diabetes (6
Below I have listed a few of my inquiries and
In the type 2 DM study, the optimal R-verapamil dosage was 60 mg/kg/day and it lowered BG and raised serum insulin
Furthermore, observational data suggest a reduced risk of type 2 diabetes
Food and Drug Administration (FDA) over 30 years ago to treat high blood pressure
ResultsThere was a In 2018, Shalev and colleagues reported the benefits of verapamil in a one-year clinical study of Type 1 diabetes patients, finding that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin, thus limiting their need for injected insulin to regulate blood sugar levels
References Original articles The suggestion that verapamil might serve as a potential Type 1 diabetes drug was the serendipitous discovery of study leader Anath Shalev, M