Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported
Benzodiazepines are best avoided
While not specifically associated with cases of drug induced liver injury, fosphenytoin is converted to phenytoin which is a well known cause of
Certain imaging tests, including transient or magnetic resonance elastography (MRE), may be recommended
And when this happens, scar tissue forms
Phenytoin derived from the metabolism of fosphenytoin is excreted in the urine primarily as hydantoin metabolites, and 1% to 5% of the fosphenytoin dose is recovered unchanged in the urine
Bilirubin
avoid taking drugs containing acetaminophen or phenytoin (Dilantin) and consult with your doctor about any other
g
Life expectancy with liver cirrhosis can vary depending on the stage of the condition, and how a person This is important in therapeutic drug monitoring because usually total phenytoin levels are reported (i
Pruritus (itchy skin, but with no visible rash)
Idiopathic/cryptogenic, around 15% (Cirrhosis), liver tissue architectural distortion, and regeneration nodule formation
Multiple-dose activate charcoal as adjunct therapy after chronic phenytoin intoxication
Drugs are much more likely to cause an asymptomatic abnormality in liver function than clinically evident liver damage or dysfunction