Dosage adjustments of the drugs * Mifepristone is a significant inhibitor of CYP3A4 when used chronically (eg, for hyperglycemia in patients with Cushing syndrome); not in single-dose use
PBPK; clarithromycin; digoxin; dose; drug interaction; midazolam
(b) Effect of a cytochrome P450 (CYP) inhibitor on the plasma concentrations of a substrate with varying fractions metabolized by the affected CYP (f m,CYP)
DDI for warfarin mainly involve moderate to strong inhibitors/inducers of cytochrome
Inhibitors
The aim of the present study was to test the hypothesis that inhibition of P