Pros • Can use for both adults and children • Available as a lower-cost generic • Available as a liquid, dissolvable tablet, and injection for people who have problems swallowing pills or are too nauseous to keep medication down Cons • Might cause headache • Can interact with certain medications, like antidepressants and migraine medications Zofran ( ondansetron) and Compazine (prochlorperazine) are prescribed for the treatment of nausea and vomiting
Prochlorperazine and ondansetron appear to be equally effective at treating vomiting in the emergency department
ANTIHISTAMINES AND Twenty-five percent of ondansetron-treated patients compared with 68% of prochlorperazine-treated patients experienced three or more emetic episodes, rescue medication use, or withdrawal from the study due to adverse events or lack of efficacy of the study drug
Efficacy of Ondansetron and Prochlorperazine for the Prevention of Postoperative Nausea and Vomiting After Total Hip Replacement or Total Knee Replacement Procedures: A Randomized, Double-blind, Comparative Trial | Orthopedics | JAMA Internal Medicine | JAMA Network 1992;9 (suppl 6) 55- 62 Ondansetron is often chosen as a front-line agent, due largely to its lack of serious side effects
Prochlorperazine (Compro) Summary
Prochlorperazine
v
given immediately after induction of anaesthesia prior to tracheal intubation
73% of reviewers reported a positive effect, while 19% reported a negative effect
3 likes, 2 comments - hoofnwoofpetfirstaid on January 8, 2024: "PARVO VIRUS : Canine parvovirus (also referred to as CPV, CPV2, or parvo) is a contagious virus m" Indications and Dosage
As prochlorperazine edisylate: Initially
Drowsiness, dizziness, lightheadedness, blurred vision, constipation, or dry mouth may occur
Maximum dose: 20 mg/day (2 to 5 years); 25 mg/day (6 to 12 years) Parenteral: Usual dose: 0
It is prescribed for a variety of unrelated conditions, including problems with balance and dizziness, sickness (nausea and vomiting), agitation and restlessness, and schizophrenia
Don't drive or do anything requiring concentration until you know how it affects you
14 g/mol
Prochlorperazine 12
vomiting of blood
dryness of the mouth
Prochlorperazine can help relieve severe nausea and vomiting associated with vertigo
It's taken in low doses for nausea and vomiting, and dizziness or vertigo caused by inner ear problems
100% of reviewers reported a positive effect, while 0% reported a negative effect
Effects on Lactation and Breastmilk
Child 12-17 years
Following intramuscular administration of prochlorperazine edisylate, the drug has an onset of action Applies to: prochlorperazine and Zofran (ondansetron) Using prochlorperazine together with ondansetron can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect
prochlorperazine and arsenic trioxide both increase QTc interval
inability to have or keep an erection
Both Phenergan and Zofran can cause changes in blood pressure and heart rate
d
Adjunct in the short term management of anxiety
4
Therapeutic options available for adults with vomiting secondary to gastroenteritis include dopamine antagonists such as metoclopramide or prochlorperazine and serotonin antagonists such as ondansetron
Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache
The risk of QT prolongation is exacerbated by electrolyte abnormalities observed in patients with ongoing emesis, particularly hypokalemia
Phenothiazines may intensify or prolong the action of central nervous system depressants (e
You can have prochlorperazine: as a tablet; Ondansetron is also available as a tablet that melts on your tongue
0 out of 10 from a total of 266 ratings on Drugs
Zofran is an Ratings & Reviews Ondansetron has an average rating of 7
For nausea, the anti-emetic ondansetron (Zofran) is very effective, but one of the side effects is headache
Antiemetics Table 1 lists the primary classes of antiemetics, as well as specific agents in each class
Ondansetron is a generic prescription drug
Efficacy of Ondansetron and Prochlorperazine for the Prevention of Postoperative Nausea and Vomiting After Total Hip Replacement or Total Knee Replacement Procedures: A
Head-to-head comparisons of medication uses, side effects, warnings, and more
Find out how prochlorperazine treats feeling or being sick, including pregnancy sickness, motion
Ratings & Reviews Ondansetron has an average rating of 7
Compazine (prochlorperazine)1 is an antiemetic drug that may be used to treat nausea and vomiting
Maximum dose: 20 mg/day (2 to 5 years); 25 mg/day (6 to 12 years) Parenteral: Usual dose: 0
Used for Anxiety, Nausea, Schizophrenia
Prochlorperazine edisylate, 2-Chloro-10- [3- (4-methyl-1-piperazinyl)propyl]phenothiazine 1,2-ethanedisulfonate (1:1), has the following structural formula: Molecular Formula: C 20 H 24 ClN 3 S
Ondansetron has an average rating of 7
The brand name Compazine is discontinued in the U
Acute gastroenteritis is caused by viral, bacterial or protozoal infections
Prochlorperazine is thought to work by blocking the action of a chemical
dryness of the mouth
5-10 mg, if necessary, may repeat dose 3-4 hourly
uncontrolled chewing movements and movements of the arms and legs
It may also be used to treat dizziness associated with problems of the inner ear such as Meniere’s Syndrome
In general, Zofran is a more common choice for treating nausea from chemotherapy, radiation, and surgeries
Prevention and treatment of nausea and vomiting
Prochlorperazine is a medicine with many different uses
1 1 CZ:L96 2 PRESCRIBING INFORMATION 3 COMPAZINE® 4 brand of 5 prochlorperazine 6 antiemetic • antipsychotic • tranquilizer 7 DESCRIPTION 8 Compazine (prochlorperazine) is a phenothiazine derivative, present in Compazine tablets and 9 Spansule sustained release capsules as the maleate
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