Apr 26, 2023 · Official answer
Mar 8, 2023 · Reconstitute vial containing ethacrynate sodium equivalent to 50 mg of ethacrynic acid with 50 mL of 5% dextrose injection or 0
ethacrynic acid may also be used for purposes not listed in this medication
Ethacrynic acid is a medication used in the management and treatment of chronic heart failure
The main complications they produce are related to the remarkable
Adult Dosing 40mg furosemide = 20mg torsemide = 1mg bumetanide = 50 mg ethacrynic acid Ethacrynic acid: 50 to 200 PO daily, adjust dose in 25mg increments Ethacrynate
, Edenbridge Pharmaceuticals, LLC and Oceanside
The objective of the study was to compare the efficacy and safety of ethacrynic acid with
Learning Objectives To raise the awareness of ethacrynic acid as substitute to furosemide for provocative diuretic renography in patients with severe cross-reaction to sulfonamide
" Ethacrynic acid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions
Day 2 - 50 mg twice daily after meals, if necessary
Because of decreased cardiac output, patients with HF have Loop diuretics that are currently approved in the USA include furosemide, bumetanide, torsemide and ethacrynic acid (Table 1)
Furosemide is a sulfonamide, and can therefore induce hypersensitivity reactions such as rash or acute interstitial nephritis
Ethacrynic acid is used to treat edema (fluid retention; excess fluid held in body tissues) in adults and children caused by medical problems such as cancer, heart, kidney, or liver disease
Hypocalcemia and hypomagnesemia had been reported in FR group and tinnitus and hearing loss had been reported in EA group during the follow-up period
Unlike other loop diuretics, ethacrynic acid is a novel drug due to the absence of a sulfonamide group in its structure, allowing its use in critically ill patients with life-threatening sulfa-allergies
An approximate dose conversion ratio is 1:20:40:50 for bumetanide: torsemide: furosemide: ethacrynic acid
The first three are usually preferred over ethacrynic acid because of the latter's increased propensity to cause metabolic alkalosis and ototoxicity
Furosemide-equivalent dosing among loop diuretic users ranged from ≤20 mg/d (8%) to >320 mg/d (1%), and dosing did not differ by dialysis vintage
Correct, Ethacrynic acid inhibits the reabsorption of sodium to a greater degree than furosemide
1969 Jul;12(1):99-118
Ethacrynic acid is an unsaturated ketone derivative of an aryloxyacetic acid