Inhibitory Effects of CQ and HCQ on the Potential Sites of SARS-CoV-2 Entry and Pathophysiology in Host Cells
“Hydroxychloroquine has showed promise in a lab setting against SARS-CoV-2, the virus that causes COVID-19 and preliminary reports suggest potential efficacy in small studies with patients
It is more water soluble, less toxic and has fever side effects than chloroquine (Table 1)
Effect of early treatment with hydroxychloroquine or lopinavir and ritonavir on risk of hospitalization among patients with COVID-19: the Abstract
an anti-malaria drug that has not been shown to be safe or effective against Covid-19
With rheumatoid arthritis, a patient’s overactive immune “While we hoped that hydroxychloroquine would help, even this is an important result as we work together to find effective treatments for COVID-19
The studies that cast doubt on hydroxychloroquine as an effective COVID-19 treatment tend to have a more rigorous design than the ones suggesting the drug may be helpful against the disease
Hydroxychloroquine (HCQ) sulfate, a derivative of CQ, was first synthesized in 1946 by introducing a hydroxyl group into CQ and was demonstrated to be much less (~40%) toxic than CQ in animals 4 In the prevention and treatment of Coronavirus disease 2019 (COVID-19) in the United States, 74% trust their health care providers
In recent times, its hydroxyl derivative, HCQ, has proven to be safer than CQ due to the decreased renal and ocular
Anthony Fauci 'lied' about the effectiveness of hydroxychloroquine in treating COVID-19
Based on the data, they concluded that hydroxychloroquine was not an effective Hydroxychloroquine continues to be a routinely prescribed, well-tolerated, effective, and low-cost treatment for rheumatic disease
Alpert, editor-in-chief of the AJM, said the journal does not endorse HCQ treatment for COVID-19