Cell growth and chondrogenic differentiation were assessed by measuring DNA content, protein and proteoglycan synthesis rates, and proteoglycan accumulation
Background aims: Dexamethasone (Dex) is a potent synthetic member of the glucocorticoid class of steroid drugs
Whether “mitotic clonal expansion” is required for adipose differentiation remains controversial
However, the mechanisms involved in the early stages of osteogenic differentiation are not well understood
Methods: Dose- and time-dependent Conclusions and clinical relevance: Dexamethasone and FGF-2 enhanced chondrogenic differentiation of MSCs, primarily through an increase in MSC numbers
Using both in vitro and in vivo approaches, this study was to determine the effects of Dex treatment on the proliferation and differentiation of human tendon stem cells (hTSCs), which can directly impact tendon healing
Cell Death and Differentiation (2001) 8, 279–288 The anti-apoptotic effects of dexamethasone in cells such as hepatocytes may thus be related to the modulation of bcl-x gene expression
Glucocorticoids play important roles in the regulation of insulin sensitivity and adipose tissue distribution
To illuminate the role of FGF-2 and dexamethasone on the differentiation of cementoblasts, we studied the level of ALP activity, the expression of RUNX2, OCN, CAP, and BSP, and calcium deposition in FGF-2 and/or dexamethasone treated cementoblasts
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Here, we examined the effects of MSCs and selected ISD (tacrolimus, cyclosporin A, mycophenolic acid, dexamethasone) treatment on early NK-cell activation