Lamotrigine is used both for seizures and bipolar disorder
Benzodiazepines may interfere with Ketamine experiences, therapeutic benefits, and may present unexpected interactions
Two out of 5 studies on lamotrigine indicated that the effects of ketamine were attenuated
Current literature shows that benzodiazepines and probably lamotrigine reduce ketamine's treatment outcome, which should be taken into account when
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Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release
Lamotrigine is an inhibitor of glutamate release and attenuates ketamine's dissociative effects
Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on
Compared to pretreatment with placebo, lamotrigine was associated with “a significant decrease in ketamine-induced dissociative symptoms” at 5 minutes and 80
A case report from 2014 reports the failure of ketamine anesthesia in a patient with lamotrigine overdose
• 3 mo
Pharmacodynamic interactions with ketamine are largely intuitive and can be predicted based on the known clinical effects of ketamine and the interacting drug
A literature search was performed
Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release
Like, kick in the face hard
But it might interfere with the dissasociation
Lamictal (lamotrigine) in doses above 100mg/day also can block ketamine efficacy
If you cannot be weaned off Lamictal, please allow 12 hours between taking Lamictal and the start of the infusion
Behavioral and cognitive Application error: a client-side exception has occurred (see the browser console for more information)
Aug 16, 2018
Lamotrigine, commonly prescribed for bipolar disorder and seizures, also negatively interacts with ketamine
In this historical cohort study, we included adult patients with TRD who received
Sparse evidence suggests that ketamine will not induce Our data suggest that BZDs may interfere with these downstream signaling steps and, therefore, relate to a sustained antidepressant effect
9% in 2004