Therapeutic modalities for the syndrome of congestive heart failure (CHF) have included a reduction in left ventricular (LV) afterload by vasodilation and/or neurohormonal modulation
Mechanism of Action Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium
As well as markedly reducing peripheral vascular resistance, and therefore afterload, amlodipine increases cardiac output and reduces stroke work
Takeaway Heart failure is a medical condition that affects your heart’s ability to pump blood as it should
Amlodipine is used to treat certain types of angina (chest pain) and other conditions caused by coronary artery disease (narrowing of the blood vessels that supply blood to the
According to the results of the study, a significant reduction was observed in the SBP level of the treatment-naive patients in the first 4 weeks of treatment with S-amlodipine 2
Carvedilol is a nonselective adrenergic blocker indicated for the chronic therapy of heart failure with reduced ejection fraction, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients
We studied the acute hemodynamic effects of molsidomine, a selective preload reducing agent, and nifedipine, a selective afterload reducing agent
3% of losartan and 43
Amlodipine is cost effective and predicted to be cost saving when compared with usual care
Methods: Studies were identified by conducting a literature survey in electronic databases, and study selection was carried out according to Amlodipine's role in relieving stable angina is due to the lowering of afterload secondary to its vasodilatory and antihypertensive properties
31 Several studies have reported a reduction in aortic regurgitant volume with short-term therapy
(%) 6 (23
Does digoxin decrease preload and afterload? 2
In large clinical studies, the sustained reduction afterload that amlodipine may produce may be associated with clinical benefit in some patients, but long-term effects on mortality rates appear neutral thus far, although recent data may suggest benefit in pure dilated cardiomyopathy
Amlodipine, sold under the brand name Norvasc among others, is a calcium channel blocker medication used to treat high blood pressure, coronary artery disease (CAD) and variant angina (also called Prinzmetal angina or coronary artery vasospasm, among other names)
reduction in peripheral vascular resistance and reduction in blood pressure
Increases in afterload expose the left ventricle (LV) to progressive volume- and pressure-mediated remodeling ()