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It works by reducing the production of uric acid in the body
Summary: In the majority of patients with gout, the mainstay of treatment for decreasing
Allopurinol, an analog of hypoxanthine, is widely used as an antigout drug, as xanthine oxidoreductase-mediated metabolism of allopurinol to oxy-purinol leads to oxypurinol
Allopurinol hypersensitivity syndrome (AHS) is a rare severe adverse effect of allopurinol with an incidence of about 1 in 1000, with a high mortality rate of 20% to 25%
Despite being a good safety profile in a wide range of patients, it has been rarely known to cause major adverse effects such as bone marrow suppression
While not specifically related to the mechanism of action in gout, febuxostat, unlike allopurinol, is a substrate of uridine diphosphate glucuronosyltransferase (UGT) 1A1, 1A3, 1A9, 2B7 and cytochrome P-450 (CYP) 1A2, 2C8, and 2C9
About allopurinol
It is a xanthine oxidase inhibitor which is administered orally
170) was approved by FDA in 1966 and is currently formulated by many manufacturers
Allopurinol is the drug most widely used to lower the blood concentrations of urate and, therefore, to decrease the number of repeated attacks of gout
Increasing amounts of uric acid also form in the body, secondary to consumption of foods rich in purines
infantum strains may enhance uncontrolled transmission to humans Introduction
Effects of Allopurinol on Secondary Outcomes
Allopurinol, an analog of hypoxanthine, has been used as an antigout drug for more than half a century and has been found to be generally effective in lowering uric acid levels in the blood ()
Allopurinol (Alloprim) is a purine analog that is the preferred and standard-of-care therapy for chronic gout
If a rash occurs while taking allopurinol, immediate discontinuation of allopurinol is required and urgent medical advice should be sought
The dosing information of allopurinol has been mentioned below : The initial dosage of allopurinol for gout is 100 mg to be taken orally once a day