In a patient with hypertensive crisis following abrupt cessation of clonidine hydrochloride
INTRODUCTION Antihypertensive medication is usually continued
The manufacturer, Boehringer Ingelheim, informed us that there were no recommendations 1
It was originally developed as a nasal decongestant, but its main use has been as an anti-hypertensive
4 However when clonidine is abruptly stopped there is the risk of rebound hypertension
A case study from 2022 noted that withdrawal from clonidine may cause significant rebound hypertension
Descriptions
Clonidine is an alpha-2 adrenergic receptor agonist which acts in the brain to decrease sympathetic outflow to the heart and peripheral vasculature
9 to 1
7 mg/day (esp
Consider tapering off Beta Blocker several days before stopping Clonidine
4 mg per day
To test the effects of GRK2 inhibitotr, we measured blood pressure by using a tail-cuff system in diabetic mice in which rebound hypertension was induced by withdrawal after clonidine treatment and measured vascular responses in isolated aortas from these mice
Management of tizanidine and clonidine withdrawal syndrome includes 3,8 the following
Rebound hypertension following abrupt cessation of clonidine and metoprolol
Lofexidine was recently approved for the treatment of opioid withdrawal, and it can also produce significant blood pressure rebound after abrupt cessation
Clonidine rebound hypertension is a well-described phenomenon, characterized by
Clonidine is used alone or together with other medicines to treat high blood pressure (hypertension)