Proper Use
Drug information provided by: Merative, Micromedex ®
Disulfiram
300 mg on day 1; add 300 mg per day (i
History: The disulfiram-like reaction in combination with alcohol was discovered incidentally by a Danish pharmacologist, Dr
Pathologic alcohol use affects more than 2 billion people and accounts for nearly 6% of all deaths worldwide
Other recommendations include: oxygen, carbogen (95% oxygen and 5% carbon dioxide)
People who engage in risky drinking often have physical and social problems related to their alcohol use
According to the National Survey on Drug Use and Health (NSDUH), almost 15 million people aged 12 and older struggle with an alcohol use disorder (AUD) in the United States
DB00822
Disulfiram and naltrexone can both help treat alcohol use disorder (AUD)
It prevents alcohol from being broken down (metabolized) by the liver
However, the maintenance dose can range from 125 to 500 mg daily
Disulfiram (Antabuse) Naltrexone (ReVia) Naltrexone injection (Vivitrol) Acamprosate (Campral) Outlook
Disulfiram is a thiuram derivative which blocks the oxidation of alcohol at the acetaldehyde stage
The unpleasant side effects usually last for between 30 and 60 minutes, but severe reactions can last several
Disulfiram works by blocking the breakdown of alcohol in the body
Manufacturer advises patients and their carers should be counselled on the disulfiram-alcohol reaction—reactions may occur following exposure to small amounts of alcohol found in perfume, aerosol sprays, or low alcohol and "non-alcohol" beers and wines; symptoms may be severe and life-threatening and can include nausea A recent meta-analysis on the efficacy of disulfiram for the treatment of alcohol dependence showed disulfiram as a controversial medication
Cephalosporins lacking these side chains appear safe to consume with alcohol
There are three medications approved for the treatment of alcohol use disorder by the US Food and Drug Administration (FDA): disulfiram, naltrexone (oral and long-acting injectable), and acamprosate