e
Phenytoin (PHT) and valproic acid (VPA) compete for the same binding sites on albumin
Valproic acid and phenytoin were equally effective in the treatment of acute repetitive seizures and status epilepticus
exp phenytoin/ or (Epanutin or Phenytek or Dilantin or Eptoin or Diphenin or Dipheninum or Diphenylhydantoin)
Applies to: valproic acid
Alcohol can increase the nervous system side effects of valproic acid such as dizziness, drowsiness, and difficulty concentrating
8 to 2
Enzyme-inhibiting medications like valproic acid can affect the metabolism of lamotrigine, increasing the level and increasing its half-life, versus medications like estrogen-containing oral contraceptives reduce lamotrigine levels by finerenone
3
A series of generalized seizures, particularly tonic-clonic, without cessation is
The man had been taking phenytoin at a therapeutic dose for epilepsy since four years
Valproic acid, or 2-propylpentanoic acid, is a branched-chain fatty acid derived from valerian acid, with Food and Drug Administration approval for treatment of seizures, migraine prophylaxis, and manic or mixed episodes associated with bipolar disorder (1, 2)
The most common of these interactions is the displacement of plasma protein-bound phenytoin by
When VPA levels are not routinely monitored or are nonsedating IV anticonvulsant (e
The effect of hypoalbuminemia on free fraction has been quantified and serves as the basis of an equation used to "correct" measured total valproic acid concentrations
3 microgram/ml when VPA
Absence seizure D
Effect of phenytoin and valproic acid therapy on serum lipid levels and liver Clinical cases of valproic acid autoinduction may be underreported
During initial therapy with valproic acid, total plasma phenytoin levels decreased
In addition, stiripentol is 99 % protein bound [ 62 ], and displacement interactions are therefore also likely to occur, but studies are lacking