Drug Images Highlights for theophylline Theophylline oral tablet is only available as a generic drug
In most individuals, a plasma-theophylline concentration of 10–20 mg/litre (55–110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma
Anxiety; arrhythmias; diarrhoea; dizziness; gastrointestinal discomfort; gastrooesophageal reflux disease; headache; hyperuricaemia; nausea; palpitations;
Theophylline is an oral bronchodilator with a narrow therapeutic window, used in the treatment of conditions such as asthma and chronic obstructive pulmonary disease
It usually is taken every 6, 8, 12, or 24 hours
5% max weight loss on drying for the anhydrous form and 7
However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day
recommendation for analytical precision and accuracy Therapeutic drug levels are lab tests to look for the amount of a drug or medicine in the blood
Theophylline clearance reaches maximal values by one year of age, remains relatively constant until about 9 years of age and then slowly decreases by approximately 50% to adult values at about age 16
When theophylline concentrations exceed 20 mcg/mL, many adverse effects may occur, including persistent vomiting, cardiac arrhythmias, and
Aminophylline
Little theophylline is excreted unchanged in the urine and active metabolites (caffeine, 3-methylxanthine) do not attain clinically significant levels even in end stage renal disease
Many people take theophylline alongside a short-acting therapy, such as an inhaler
Check more regularly in older people or those with heart failure or hepatic impairment
Bronchodilators open up the airways to assist breathing
) plasma theophylline concentration on day 3 was 12
Plasma theophylline levels during treatment with placebo and 32 h after the last dose of active drug were all <1
31 hours