There is an emerging literature suggesting that discontinuing antipsychotics, in particular clozapine, can cause an array of withdrawal symptoms
Discontinuing clozapine in patients with schizophrenia is associated with an increased risk of relapse of psychotic symptoms
In these cases, clozapine discontinuation was frightening, with a loss of control over mental health and feelings of hopelessness or failure
Clozapine withdrawal symptoms | Psychiatric Bulletin | Cambridge Core > >BJPsych Bulletin >Psychiatric Bulletin >Volume 18 Issue 3 >Clozapine withdrawal symptoms
A wide spectrum of somatic and psychiatric symptoms have been reported (Figure 1), including psy-chotic, autonomic
Heart disease: signs of a problem include chest pain
An editorial pointed out that mortality from agranulocytosis occurs in 0
It has a median incidence of 287 (uncertainty interval 246–331)/100,000 [] and median standardized mortality ratio of 2
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In the case of clozapine, recognized withdrawal symptoms include rebound psychosis 75 and rebound movement disorders Clozapine belongs to a group of medicines called antipsychotics
In rarer cases, withdrawal can lead to serotonin syndrome, seizures, and even catatonia
Despite these challenges for the clinician, there is currently no formal guidance on how to safely to discontinue clozapine
pains in the stomach, side, or abdomen, possibly radiating to the back
日本では2009年6月より、商品名 クロザリル (Clozaril)が ノバルティスファーマ より発売されている。
The withdrawal symptoms and delirium resolved rapidly with resumption of low doses of clozapine
Clozapine is the medication of choice for those with treatment-resistant schizophrenia
Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery
, agranulocytosis, myocarditis, seizures) limit its widespread use
You can find detailed information about this drug in the official Patient Information Leaflet (PIL)
If compared with remaining first-generation antipsychotic agents, clozapine is characterized by a lack of extrapyramidal side-effects []
Clozapine withdrawal symptoms may result from any scenario in which receptor binding abruptly decreases
In the case of clozapine, recognized withdrawal symptoms include rebound psychosis 75 and rebound movement disorders including dystonias and dyskinesias 76,77
22 The premature discontinuation of clozapine because of fear of agranulocytosis could lead to development or Clozapine multi-receptors profile seems to be responsible for withdrawal symptoms--several specific mechanisms are suggested: cholinergic supersensitivity, dopaminergic supersensivity, special role of D4 receptors, possibilities of serotonergic, noradrenergic and GABA-ergic involvement