Reproduction studies have been performed in rats at doses up to 20 times the human dose, and in rabbits at doses up to 25 times the human dose (on a mg/kg basis), and have revealed no evidence of impaired fertility or harm to the fetus due to dimenhydrinate
The name of this medication is dimenhydrinate
Searle in 1949
Medscape UK - Indication-specific dosage for Cinnarizine with dimenhydrinate oral, precautions and warnings, side effects, pregnancy and lactation, contraindications and full drug monograph The manufacture recommends against the use of cinnarizine and dimenhydrinate tablets in pregnancy
Chronic abuse of antihistamines can lead to drug interaction accidents, overdose, and in extreme cases to death (see OVERDOSE)
Age 2 to 5 Years: 12
Reduction in Mean Vertigo Score (VS M) After Treatment With Fixed Combination (Cinnarizine and Dimenhydrinate) or Betahistine for 1 and 4 Weeks (Intent-to-Treat, per-Protocol) Time-point Medscape - Indication-specific dosing for Dramamine, (dimenhydrinate), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
dimenhydrinate increases and lisdexamfetamine Dimenhydrinate shows side effects like Drowsiness, excitement, or hyperactivity (especially in children), headache, new or worsening dizziness, blurred vision, ringing in the ears, dry mouth, nose, or throat, problems with coordination, fainting, dizziness, nausea
dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx : combo may incr
Oral
May cause drowsiness (can be used to offset anxiety caused by metoclopramide or Follow weight-based dosing
The risk of fetal abnormalities was not increased following maternal use of Small, occasional doses of dimenhydrinate would not be expected to cause any adverse effects in breastfed infants
Use Caution/Monitor
Find medical information for dimenhydrinate on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures
While similar, both medications contain key differences, including their active ingredients and dosing guidelines
Injectable solution
Adult dosage: 50-100 mg orally/IV/IM every 4-6 hours as needed, 30 minutes before exposure to motion; not to exceed 400 mg/day Medscape - Indication-specific dosing for apricot vine, corona de cristo, Fleischfarbige passion flower in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
If any of these effects last or get worse, tell your doctor or pharmacist promptly
Cinnarizine, is approved for nausea, vomiting, motion sickness, inner ear disorders and is considered as first-line pharmacotherapy for management of vertigo
News & Perspective Drugs & Diseases CME & Education dimenhydrinate increases toxicity of meclizine by pharmacodynamic Overview
News & Perspective Drugs & Diseases dimenhydrinate
Methylprednisolone 16 mg orally or IV q8h for 3 days, tapered to the lowest effective dose, can be used if persistent vomiting occurs despite the above therapy
News & Perspective ashwagandha increases effects of dimenhydrinate by pharmacodynamic synergism
It has also been used for its sedative properties and to reduce itchiness associated with allergies
(kava), frequency-based adverse effects, comprehensive Medscape - Indication-specific dosing for humulus lupulus (hops), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
Concomitant use with other preparations containing diphenhydramine, including oral and topical preparations, is contraindicated
50-100mg every 4-6 hours, starting ½-1 hour before travel; max 400mg/day
In considering treatment for motion sickness, the medical provider and the patient must understand that prevention is much more effective than trying to "cure" symptoms once they have started
Vd: 16 L/kg (adults); 23 L/kg (elderly) Dimenhydrinate (Dramamine, Gravol, Goli M, Simbar M
[QxMD MEDLINE University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference Disclosure: Received salary from Medscape for employment Dramamine (®) is an antihistamine medicine usually given to dogs to prevent vomiting and to control the symptoms of motion sickness
Evidence-Based Approaches to Managing Nausea and Vomiting in Early Pregnancy Tekoa L
Nausea and vomiting occur in up to 74% of pregnant women, and 50% experience vomiting alone
Pregnancy Patient Education Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling
“Dimenhydrinate may
GRAVOL (dimenhydrinate) has substance abuse potential due to its hallucinogenic and euphoric effects
Tell your doctor before taking if you have phenylketonuria (PKU)
rate; decr
2-6yo: 12
While similar, both medications contain key differences, including their active ingredients and dosing guidelines
25 mg/kg IV/IM; maximum single dose of 25 mg; May repeat dose once after 4-6 hours if required; The benefits of dimenhydrinate for pregnant women must be weighed against the risk
Adults and children age 12 years and up: The typical dose is 50 mg to 100 mg every 4 to 6 hours
“Dimenhydrinate may be taken during pregnancy if recommended by an OB-GYN,” Dr
Motion sickness, Nausea and vomiting, Vertigo
Injectable solution
Adult dosage: 50-100 mg orally/IV/IM every 4-6 hours as needed, 30 minutes before exposure to motion; not to exceed 400 mg/day Dramamine side effects
blurred vision
Dimenhydrinate is an antihistamine that reduces the effects of natural chemical histamine in the body
Dramamine is generally considered safe during pregnancy because as a Class B medication no risks have been found in animal studies
decreases central histamine effects
Drowsiness, constipation, blurred vision, or dry mouth /nose/throat may occur
At higher doses, confusion, hallucinations, temporary amnesia and paranoia may occur
Dimenhydrinate (brand names: Dramamine®, Gravol®, Travtabs®, Driminate®, Triptone®) is an antihistamine used to prevent motion sickness and to treat nausea, especially in dogs with vestibular disease
Currently, physicians may use all of these tools to diagnose pregnancy at early gestation and to help rule out other pathologies