Females planning a pregnancy should discontinue the HMG-CoA reductase inhibitor 1 to 2 months prior to
The main way it works is by blocking an enzyme (protein) in your liver that makes cholesterol
, sepsis; shock; severe hypovolemia; major surgery; trauma; severe metabolic, endocrine, or electrolyte Simvastatin therapy should be discontinued immediately if myopathy is diagnosed or suspected
VYTORIN should be discontinued immediately if markedly elevated creatine kinase (CK) levels occur or myopathy is diagnosed or suspected
"There are no clear guidelines after 75,” says cardiologist Dara Lee Lewis, M
It is important to discuss this with your Doctor
In many cases, these interactions can increase the risk of muscle pain and damage
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The presence of these symptoms and a CK level > 10 times the upper limit of normal indicates myopathy
Periodic CK determinations may be considered in patients starting therapy with simvastatin or whose dose is being increased, but there is
In animal studies, reduced weight gain was observed in rat Merck, known as MSD outside the United States and Canada, today said that the company will voluntarily discontinue distributing JUVISYNC™ (sitagliptin and simvastatin) tablets to pharmacies and wholesalers in the United States and Puerto Rico
To make sure it’s safe for you, tell your doctor if you: have ever had an allergic reaction to simvastatin or any other medicine
Less evidence of clinical benefit since approval