GlaxoSmithKline (GSK), the manufacturer of Zofran, was required by FDA to conduct a thorough QT study to assess the potential for the drug to prolong the QT interval
A narrow QRS complex (<120
ECG alterations: Arrhythmias; prolongation of PR, QRS, and QT intervals Hepatobiliary: Specific hepatic enzyme abnormalities, hepatic necrosis, and abnormal hepatic function General: Flushing, When analyzing an ECG with a wide QRS complex, a systematic approach should be used, which includes the following steps : (1) identification of each QRS present, their regularity, and their global representation in the 12
Learn about sinus rhythm with wide QRS with Radcliffe Cardiology
Those confounding factors included: planned co-administration of any known QT interval prolongation, signs or symptoms of cardiac ischemia, known
The long QT syndrome (LQTS) is characterized by a prolonged QT interval, as well as a propensity to develop syncope and sudden cardiac death caused by the
Most commonly due to bundle branch block or left ventricular hypertrophy
Tachycardias are broadly categorized ( algorithm 1) based upon the width of the QRS complex on the electrocardiogram (ECG)
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There are 89,438 people reported to have side effects when taking Zofran
This is very common and a significant finding
2017
Wide QRS complex is present when the normal activation pattern is modified by various mechanisms and clinical conditions
Certain physical findings can help categorize the patient in a toxidrome pattern, which together with the ECG findings may help identify toxin fQRS also had diagnostic value for detection of a myocardial scar in patients with CAD and a wide QRS complex
The attention of regulatory agencies, researchers and clinicians has been directed towards drug-induced QT-interval prolongation and its well-documented proarrhythmia
This interval represents the time taken for the ventricles to completely repolarise after activation
This is a very common and significant finding
Wide QRS complex tachycardia is a type of abnormal heart rhythm that is characterized by a widened QRS complex on an electrocardiogram (ECG) and a rapid heart rate
Widening of the QRS complex – in the setting of left bundle-branch block (LBBB) or right bundle-branch block (RBBB) – leads to QT-interval prolongation without significant alterations to the repolarization duration
The ECG shows normal sinus rhythm at 56 bpm with normal atrioventricular and intraventricular conduction and Measurement of the QT interval is also difficult in the setting of a wide QRS complex related to either ventricular conduction defects or a paced QRS complex
WCT can be loosely divided into 2 types: ventricular tachycardia (VT) and Response to ECG Challenge
However, at faster heart rates, the 50-ms adjustment may underestimate the QTc
Errors are made because emergency care professionals wrongly consider VT unlikely if the patient is hemodynamically stable, and they are often unaware of the ECG findings that quickly and accurately distinguish VT in
Procainamide is a medication used to manage and treat ventricular arrhythmias, supraventricular arrhythmias, atrial flutter/fibrillation, and Wolf-Parkinson-White syndrome