One pharmacokinetic study recovered 43 to 87% of a lamotrigine dose in the urine mainly as glucuronidated metabolites
• Abstract Background
Abstract The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy
Steady-state peak concentration (Cmax, ss) values of serum lamotrigine are, on average, 12
Purpose Lamotrigine was previously reported to reduce serum concentration of quetiapine
Lamotrigine – Mechanism of Action, Efficacy, Side Effects and Clinical Pearls
3 L/kg
Subsequent pharmacokinetic studies revealed complete oral absorption Lamotrigine (LTG), a new generation antiepileptic drug (AED), is approved as adjunctive therapy for partial seizures as well as generalized seizures of Lennox-Gastaut syndrome in adult and pediatric patients aged ≥ 2 years
Introduction
123 Pharmacokinetics and Drug Metabolism: The pharmacokinetics of lamotrigine have been 124 studied in patients with epilepsy, healthy young and elderly volunteers, and volunteers with 125 chronic renal failure
Lamotrigine exhibits first-order linear pharmacokinetics
Lamotrigine is known to be taken up by plants, but its plant-derived metabolites and their distribution in different plant organs are unknown
The kinetics of lamotrigine (LTG) disposition in plasma and saliva was evaluated in patients undergoing long-term antiepileptic drug therapy
Clinical pharmacokinetic data of Lamotrigine are summarized in several review articles [77–82]
Lamotrigine and vigabatrin in combination may be associated with synergistic efficacy in patients with partial and secondary generalized tonic-clonic seizures consequent to a pharmacodynamic interaction
Abstract
Polepally
Purpose The aims of this study were to develop a population pharmacokinetic (PPK) model of lamotrigine (LTG) in Chinese epileptic children by using nonlinear mixed effects modeling (NONMEM) and to investigate the effects of valproic acid (VPA) and genetic polymorphisms of the major metabolizing enzymes (UGT1A4, UGT2B7) on the
Effects on lamotrigine pharmacokinetics not evaluated; may be similar to those of oral contraceptives
Methods: An open-label, conversion study was conducted, consisting of a 2-week LTG-IR Baseline Phase, followed by a 2-week LTG