S395457 Abstract Fibromyalgia (FM) is a chronic pain sensitivity syndrome characterized by diffuse musculoskeletal pain and
Abstract
Low-dose naltrexone (LDN) is used widely as an off-label treatment for pain despite limited evidence for its effectiveness
It comes in a pill form or as an injectable
“We’ve discovered that, if you give patients doses far less than 50 mg, we may be able to achieve pain relief,” says Dr
But few doctors or patients seem to know about it
This medication is typically taken by mouth once daily
Do not begin using opioids at the doses you tolerated prior to starting naltrexone
For narcotic addiction: Adults—At first, 25 milligrams (mg) (one-half tablet) for the first dose, then another 25 mg 1 hour later
Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 signaling in addition to systemically
More common side effects in people taking naltrexone for alcohol use disorder include: nausea chest pain
headache
Long-acting, sustained-release opioid agonist preparations have been
fast or pounding heartbeat
Low-dose naltrexone has been used off-label for treatment of pain and inflammation in multiple sclerosis, Crohn's disease, fibromyalgia, and other diseases
Naltrexone can be prescribed to people with alcohol dependence