9 +/- 8
RESULTS Prolactin levels were obtained in 449 subjects on verapamil (35
012, χ 2-test)
Prolactinomas are noncancerous tumors made up from lactotrophs in the pituitary gland
The authors estimated that a nursing infant would receive less than 0
Verapamil, a phenylalkylamine calcium channel blocker, causes a doubling of serum prolactin (PRL) levels in humans
There have been some reports of galactorrhea (milk production that is not related to breastfeeding) among people who have taken verapamil
To determine the mechanisms by which calcium channel blockade with verapamil causes hyperprolactinemia, the authors investigated the effects of this
Verapamil, a phenylalkylamine calcium channel blocker, causes a doubling of serum prolactin (PRL) levels in humans
High levels of prolactin can stop ovulation (part of the menstrual cycle when an ovary releases an
What is verapamil? Verapamil belongs to a class of medications called calcium-channel blockers
The effects of the intravenous administration of a calcium channel blocker, verapamil (0
It is the most common type of hypothalamic-pituitary dysfunction and it is an important condition to consider in young women with fertility issues or irregular menstruation
, researched the mechanism of this effect of verapamil, a calcium channel blocker
This review will provide an overview of prolactin physiology, the role of stress Hyperprolactinemia is the most common hypothalamic-pituitary dysfunction, being an important cause of irregular menses and infertility amongst young women
By six weeks after delivery, estradiol secretion A prolactinoma is the most common cause of hyperprolactinemia
Conversely, cimetidine has the highest correlation of the H2 However, the verapamil was not able to block the large pharmacologic amounts of dopamine generated from the L-dopa or block the large dopamine effect from the dose of bromocriptine used in this study
2
Rises in blood prolactin levels have been reported Prolactin, also known as lactotrophin, is a hormone which is secreted by the lactotroph cells in the anterior pituitary gland, a small gland located at the bottom of the brain
The diagnosis is based on measuring the blood levels of the hormone prolactin
Verapamil blocks hypothalamic production of dopamine9 Gastrointestinal medications Metoclopramide,9 prochlorperazine11 Dopamine receptor antagonism9 Prolactin elevations may be dose-related; however, antipsychotics with a higher relative risk of increasing prolactin tend to raise prolactin levels even at verapamil has a significant prolactin releasing effect - a study revealed that 8
In a rat pituitary perifusion-immunoprecipitation system, verapamil (50 microM) prevents the inhibitory effect of increased extracellular Ca2+ (5
Verapamil was discontinued and, at 4 weeks, her prolactin level had decreased to 10 ng/mL
1983 May 1;51(8):1466-7