Mechanism of action
Parenteral: Recommended dose: 100 to 320 mg IM or IV once a day
Common side effects of phenobarbital include central nervous system depression, drowsiness, dizziness, vertigo, balance, coordination and speech impairment (ataxia), slurred speech (dysarthria), repetitive involuntary eye movements (nystagmus), abnormal skin The RCPCH and NPPG position statement Choosing an Oral Liquid Medicine for Children states that recommended practice in the UK is to use an ethanol-free unlicensed 50 mg/5 mL liquid for the oral administration of phenobarbital to children when an oral liquid is required
1- and 9
Efficacy of levetiracetam as first-line therapy for neonatal clinical seizures and neurodevelopmental outcome at 12 months of age
Significance: These results demonstrate effects on children's mental ability due to prenatal PB exposure, such that analyses adjusted for maternal IQ scores, revealed reduced
Introduction Neonatal seizures affect 1 to 3
Prenatally phenobarbital + phe‐nytoin‐exposed neonates had a significantly smaller occipitofrontal circumference (OFC) than prenatally
When the data were evaluated further, it was found that 24 of 30 neonates in the phenobarbital group and 21 of 29 in the phenytoin group had about an 80 percent
The most common adverse effects seen in cats on phenobarbital include balance issues when walking, drowsiness, facial itching, an excessive need to eat (leading to weight gain), and excessive
Phenobarbital is a barbiturate that reduces excitatory synaptic responses by acting on GABA A receptors
Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids, with high concentrations in the brain, liver, and kidneys
A barbituric acid derivative that acts as a nonselective central nervous system depressant
There are 15 disease interactions with phenobarbital which include: acute alcohol intoxication
respiratory depression
Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids, with high concentrations in the brain, liver, and kidneys
For seizures: If seizures are worse or not the same after starting Luminal (phenobarbital injection)
[]A mother was taking phenobarbital 390 mg daily and phenytoin 400 mg daily during pregnancy
Signs of a barbiturate overdose include clammy skin, dilated pupils, shallow respiration, rapid and weak pulse, and coma
AU TGA pregnancy category: D
Many studies have shown a significant reduction in bone mineral density (BMD) and an increased fracture risk in patients treated with enzyme-inducing antiepileptics (phenobarbital Phenobarbital was associated with a significantly decreased risk of respiratory complications, defined by the occurrence of intubation (15/76 phenobarbital [20%] vs
A usual loading dose of phenobarbital for the treatment of seizure is ~15-20 mg/kg
Front-loaded phenobarbital dose (10 mg/kg IV infusion over 30 min) from
In mild to moderate cases, symptoms can include drowsiness, confusion, dysarthria, lethargy, hypnotic state, diminished reflexes, ataxia, and hypotonia