9% (placebo) for Hunt and Hess Grades IV or V
nimodipine 30 mg In animals, nimodipine and/or its metabolites appear to undergo extensive enterohepatic circulation; possible enterohepatic circulation in humans
It also has other off-label indications
Nimodipine is isopropyl 2 -methoxyethyl 1,4 –dihydro -2,6 –dimethyl -4- (m-nitrophenyl) -3,5-pyridinedicarboxylate
In patients who develop adverse reactions the dose should be reduced as necessary or the treatment discontinued
DESCRIPTION
Solution
Dihydropyridines: nifedipine (Procardia, Adalat), amlodipine (Norvasc), clevidipine (Cleviprex), nicardipine (Cardene), felodipine (Plendil), nimodipine (Nimotop) Non-dihydropyridines: diltiazem (Cardizem), verapamil (Calan, Isoptin) CLASS: Calcium Channel Blockers (CCB) MECHANISM OF ACTION: Block the entry of calcium into the cells NAME OF THE MEDICINE
anterior cerebral artery
By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent The nimodipine studies are sequentially referred to as HIT (Head Injury Trial) I-IV
Adult: Initially, 1 mg/hr infusion for 2 hr given via bypass into a central vein, increase to 2 mg/hr if no severe decrease in BP is observed
Moreover, nimodipine also dramatically decreased the mortality [RR, 0
, good recovery) on the Glasgow Outcome Scale was 25
14 Hypotension starts to occur at a 30-ng/mL plasma nimodipine concentration