This translates to a 2,060% increased risk of spina bifida compared to non-exposed babies
All women of reproductive age should get 400 micrograms (mcg) of folic acid each day, in addition to consuming food with folate from a varied diet, to help prevent neural tube defects (NTDs)
Depakote (valproate semisodium or divalproex) is the brand name of a drug which was first approved in the early eighties for the treatment of epilepsy
The drug has been linked to cognitive problems (such as decreased IQ scores, autism, and Asperger
Before using any of these medications, women who can become pregnant should consider the fact that these medications have been associated with birth defects
Spina bifida occulta, or hidden spina bifida, is a mild form of spina bifida
Antiepileptic drug therapy with valproic acid (VPA) during early pregnancy can result in a 1-2% incidence of spina bifida aperta, a closure defect
no visible opening outside
These defects occur in 1
Louis jury has determined that AbbVie should pay $15 million to the family of a Minnesota girl born with spina bifida, indicating that the drug
Spina bifida is a neural tube defect that occurs early during pregnancy
An ultrasound (sonogram): Problems Spina bifida is a condition that occurs when the spine and spinal cord don't form properly
Depakote, Trileptal), and poorly-controlled diabetes prior to pregnancy
Response usually is seen when the blood concentration of valproic acid is 50-100 mcg/mL
It can be further subdivided into spina bifida occulta and spina bifida aperta
Developing independence can be especially challenging for children with spina bifida
Each year, about 1,427 babies are born with spina bifida, or 1 in every 2,758 births
NTDs have complex and multifactorial etiologies in which both genetic, life style and environmental factors appear to be involved
The neural tube that develops into the brain and spinal cord does not form correctly, leaving an opening in the spinal column that exposes the spinal cord
Taking valproate during pregnancy increases the risk of having a baby with malformations, abnormalities such as spina bifida and developmental problems after birth, including autism and learning DEPAKOTE may harm your unborn baby
Careful antenatal planning and management of the complications can optimise outcome
Furthermore, it has been estimated that there is a However, another contributing factor is Depakote (which is also sold under the names Depakene, Epilim, and Stavzor)
Reported by a lawyer from United States on 2012-08-16 Patient: female Reactions: Neural Tube Defect, Spina Bifida, Pain, Foetal Exposure During Pregnancy, Deformity, Emotional Distress, Social Problem, Anhedonia, Loss of Employment, Congenital Anomaly, Injury, Physical Disability, Tension Drug(s) suspected
And in 2011 the FDA issued another warning, claiming that there was a correlation between Depakote and diminished cognitive abilities