Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe form of drug hypersensitivity reaction with significant morbidity and mortality, potential for long-term sequelae and limited treatment options [ 1 ]
At diagnosis, she had an eosinophil level of 1,992 cells/mcL (normal range, <500 cells/mcL), leukocyte
The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction
If this syndrome is recognized, the Ampicillin and minocycline are the most commonly implicated drugs
In a group of 9 patients with minocycline-induced DRESS syndrome with skin phototypes V and VI; 6 patients had significant plasma and skin levels of minocycline ranging from 11
7,8 In patients who have renal failure, minocycline does not accumulate but may aggravate uremia
10 It would be prudent for dermatologists to consider DRESS is an immune-mediated reaction to a drug
Background: While many cases of DRESS reaction to minocycline have been described, few of these involve doxycycline
Neurologic involvement in DRESS is uncommon but well described and most commonly manifests as meningitis
It is also used to treat acne
DRESS syndrome is rare (1/5000–10000 prescriptions of each of the causal drugs)
1 depicts a treatment algorithm, modified from the Spanish group's guidelines