Next: Interactions
Manufacturer advises adjust Aripiprazole dose
The reduced form of vitamin K is necessary for the carboxylation of the terminal regions of the vitamin K proteins, factors II, VII, IX, and X
Minor
Older AEDs, acting on cytochrome P450 isoenzymes, and especially on CYP3A4, such as phenobarbital, phenytoin, and carbamazepine are more likely to
fluoxetine
Many drugs have been implicated in drug-induced immune thrombocytopenia (DITP)
Of the total drug interactions, 64 are major, 168 are moderate, and 17 are minor
Dabigatran causes bleeding, as can Ticagrelor ; concurrent use might increase the risk of developing this effect
Manufacturer advises monitor and adjust dose
Severity: Moderate Evidence: Study
Manufacturer advises use with caution or avoid
Apr 13, 2020 · Implicated drugs included commonly prescribed drugs such as warfarin, clopidogrel, carbamazepine, and allopurinol
warfarin, dabigatran or clopidogrel – medicines used to help prevent blood clots; carbamazepine – for epilepsy and nerve pain; losartan – for high blood pressure and heart failure; statins – for high cholesterol; These are not all the medicines that can affect fluconazole
John's wort, and clopidogreldoses may need to be reduced if aCYP3A4 inducer is coadministered
Sep 4, 2020 · The antiplatelet drug clopidogrel is sequentially activated by CYP450 isoforms, including CYP2C19, into its active metabolite (H4)
For this indication, treatment with rivaroxaban is usually long term
Carbamazepine is not suitable for some people
Fluoxetine: Major interaction [reduced levels of active metabolite of clopidogrel via CYP2C19 inhibition] ADVICE Mar 1, 2021 · 1
4,5 Although these findings sound interesting, not all patients treated with these drugs experience some degree of
Pruritus accounts for about 5% of all skin adverse drug reactions (ADRs) after administration
This can make doxycycline less effective, which could lead to an undertreated infection