In January 2012, a large control study published in the medical journal Birth Defects Research Part A: Clinical and Molecular Teratology found a link between Zofran and cleft palate, indicating that women prescribed the medication for morning sickness during the first trimester may be 2
1 A small percentage will develop hyperemesis gravidarum, which is the most common indication for hospital admission during the first part of pregnancy
Despite several studies showing no clear benefits of ondansetron over other NVP treatments such as doxylamine, and the paucity of safety data, the off-label
An association between second-trimester hyperemesis gravidarum and placental dysfunction (eg, preeclampsia, abruption, SGA) was reported in a population
Most research
The drug is not labeled for use in NVP in either the United States or Canada
Associations between first trimester ondansetron exposure and cardiac malformations persisted but were weakened as the outcome was expanded to include
It was designed originally for chemotherapy-induced nausea and vomiting
Various recent studies have linked Zofran to significant increased risk of birth defects including The second study by Dr
Birth defect risks include cleft palate and septal heart defects
A recent scientific study published in Reproductive Toxicology presents possible links between the use of Zofran and specific birth defects that affect the heart, as Zofran usage during the first trimester was connected with a 237% higher risk of cleft palate birth defects
Use of antihistamine medications during early pregnancy and isolated major malformations
This has been confirmed through genetic testing
The first study was considered biased because more than half the women in the study took Zofran after the first trimester
Zofran taken during pregnancy may have caused damage to the developing fetus, resulting in congenital malformation or birth defects
Zofran (51 questions, 77 members) Ondansetron (23 questions, 35 members) Zofran ODT (1
First trimester exposure to ondansetron was associated with increased risk of cardiac (OR: 1
The most common side effects of taking Zofran during pregnancy include: Fetal growth restriction
One method involves looking at registries of children born with birth defects and asking their mothers what medications they remember taking during their pregnancy
The A study of data from 2,000 women who took Zofran among 600,000 births in Denmark from 2004-2011 found no significant increased risk of birth defects