Fenofibrate is more effective than statins at increasing HDL cholesterol levels, similar to atorvastatin and rosuvastatin at reducing triglyceride levels, but less effective than statins at lowering LDL cholesterol levels
Methods
There are three agents of choice in the fibric acid drug class: fenofibric acid, fenofibrate, and gemfibrozil
Discontinue fibrate therapy or reduce the fibrate dose if a clinically significant elevation of serum creatinine occurs in the patient, after excluding all possible causes for the same
However, in a sub Objective: To compare the hypolipidemic effects of gemfibrozil and micronized fenofibrate in patients with primary hyperlipoproteinemia, phenotypes IIa and IIb, with emphasis on their cholesterol-lowering effectiveness
A 67-mg micronized capsule of fenofibrate is the bioequivalent of a 100-mg, non-micronized tablet
Methods: The primary endpoint was absolute change in TG levels
Pancreatitis has been reported in patients taking fenofibrate, gemfibrozil, and clofibrate
If cholelithiasis is suspected Most studies evaluated fenofibrate and bezafibrate, and only 1 study evaluated pemafibrate
Fenofibrate is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood
Common side effects of gemfibrozil include gastrointestinal upset, diarrhea, constipation and fatigue
Other side effects not listed may also occur in some patients
The mean duration of gemfibrozil therapy for the study cohort was 23 ± 19 months (median 17
The major concern when using a statin-fibrate combination is the potential increased risk for myopathy and rhabdomyolysis