Influence of commonly used excipients on the chemical degradation of enalapril maleate in its solid state: The role of condensed water
To improve the stability of EM, the degradation mechanism should
Proposal of a new degradation mechanism of enalapril maleate and improvement of enalapril maleate stability in tablet formulation with different
4% for drug in purified water, 54
The metabolism of drugs occurs through basic chemical reactions as soon as the administered compound comes into contact with enzymes that are capable of altering its chemical structure
The effect of humidity and temperature on the stability of enalapril maleate (ENA) in tablets have been studied
Enalapril is also used in combination with other
Presumably due to the inhibition of the degradation of endogenous bradykinin, persistent nonproductive cough has been reported with all ACE inhibitors, always resolving after discontinuation of therapy The degradation of enalapril maleate has been followed by using an HPLC method, which was demonstrated to be specific, stability indicating, accurate and precise
It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol
Enalapril maleate powder is stable against moderate heat and humidity; 40°C and 75% RH
To improve the stability
] To the cooled residue in the beaker add 50 mL of acetonitrile, and sonicate for a few minutes to dissolve
The following retention time for the substances, internal standard and product of deacay were obtained: approximately 4, 6 and 2, 3 min
The in situ preparation of enalapril sodium salt (NaE) has been used to improve drug stability in dosage forms; however, gas release and
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In this study, we found that several commonly used excipients promoted the degradants of EM, particularly a diketopiperazine derivative (DKP)