Mechanism of Action Colchicine has primarily anti-inflammatory properties
Colchicine has multiple mechanisms of action that affect inflammatory processes and result in its utility for treating and preventing acute gout flare
Mechanism of Action
Mechanism of Action Disrupts cytoskeletal functions by inhibiting β-tubulin polymerization into microtubules, preventing activation, degranulation, and migration of
Mechanism of Action
Its mode of action includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes with
In this issue of Nature Metabolism, Weng
Colchicine interferes with many inflammatory pathways, including adhesion, superoxide production, inflammatory activation, and proinflammatory cytokine release
Newly described mechanisms include various inhibitory effects on macrophages including the inhibition of the NACHT-LRRPYD-containing protein 3
Although the exact mechanism of action remains incompletely elucidated, data show that colchicine also suppresses
Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness and its mode of action
An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint
It is predominantly metabolized in the gastrointestinal tract
The most studied therapeutic mechanism of action of colchicine is its capacity to bind to tubulins, thereby blocking the assembly and polymerization of microtubules
At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3)
Colchicine has been widely used as a research tool in the study of microtubules
It is predominantly metabolized in the gastrointestinal tract
Its main effects are achieved through selective inhibition of peripheral H1 receptors
12
, Parks W
A mechanism for matrix metalloproteinase activation and atherosclerotic
Colchicines have a low therapeutic index with several toxicities: neutropenia, gastrointestinal upset, bone marrow damage and anaemia
Although the mechanism of action of phenazopyridine lacks definitive substantiation, it is hypothesized that the drug exerts a localized analgesic effect on the urinary tract mucosa
Kamovskyl3 has reported significant measurable increases in lactic acid pro-