The 5-alpha reductase inhibitor (5-ARI) dutasteride (Avodart) likely is the most efficacious among the three drugs currently used to treat androgenetic alopecia
Thus, 5-alpha reductase inhibitors (5-ARIs) effectively reduce the serum and intraprostatic concentration of DHT, causing an involution of prostate tissue
Missed doses of dutasteride, a newer 5-alpha-reductase inhibitor, are not likely to impact drug-induced suppression of dihydrotestosterone (DHT), and clinically
3 5α-reductase inhibitors (5ARI) include finasteride and dutasteride, and are commonly prescribed in the treatment of benign prostatic hyperplasia and
Get emergency medical help if you have any of these signs of an allergic reaction to Avodart: hives; difficulty breathing; swelling of your face
The study investigators found a decreased risk of dying of prostate cancer in men treated for LUTS with 5-ARI for more than 2 years compared with men not treated
The objective of this study was to determine whether men taking 5
Men receiving testosterone supplementation who also receive the 5-alpha-reductase inhibitor dutasteride (Avodart) do not experience a significant difference in
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Avodart 500 microgram/day (n = 1,623), tamsulosin 400 microgram/day (n=1,611) or the combination of Avodart 500 microgram plus tamsulosin 400 microgram (n=1,610) administered once daily [total number of patients = 4844] were evaluated in men with moderate to severe symptoms of BPH who had prostates ≥ 30 mL and PSA values
It works by blocking the production of a hormone called dihydrotestosterone (DHT), which can contribute to the growth of the prostate
The authors reported that 5-ARI users had longer delays from first “adjusted” elevated PSA to prostate biopsy (3
Gynecomastia occurred in 5
3), Adverse Reactions (6
Reclassification occurred in 17% of 5-ARI users compared with 31% of non-users (P =
Finasteride
The 5-ARI class of drugs, in addition to reducing prostate size, also reduce the need for future BPH-related Treatment with a 5-ARI is a potential alternative, or in the case of α1-ARA therapy, starting with alfuzosin may be the first choice
Rather, DHT levels rise slowly increasingly just 15-20 % after the second day (ie from 25-30 ng/dL up to 30-35 ng/dL)
Several clinical studies have indicated that former 5-ARIs users had a higher incidence of depressive symptoms and neuropsychiatric side effects than non-users
American Urological Association (AUA) guidelines advise that in men with lower urinary tract symptoms (LUTS) and enlarged prostates, 5-ARIs may help prevent progression of LUTS secondary to BPH and reduce