Side effects Warnings Before taking Dosage Interactions What is nevirapine? Nevirapine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying
Carr and Cooper state that corticosteroids are not preventive, antihistaminics provide no proven benefit, and desensitisation might be risky, since nevirapineresistant
Do not use prednisone to prevent a rash because it can actually increase the risk of a rash during the first 6 weeks of nevirapine treatment
Women have a higher risk of developing a rash during treatment
In an analysis of the four major controlled development trials, the frequency of rash of any severity was 35% in 350 nevirapine-treated patients compared with 19% in
It’s best to start them within 3 days of a rash or blisters developing
Delay in stopping nevirapine treatment after the onset of rash may result in a more serious reaction
Metabolism: Nevirapine (NVP) is metabolized by and induces hepatic CYP3A and CYP2B6; autoinduction of metabolism occurs in 2 to 4 weeks of NVP dosing, leading to a 1
Risk of side effects associated with the use of nevirapine in treatment-naive patients, with respect to
Severe rash has been observed in 3% of patients taking nevirapine in clinical trials, 85% of whom were men
Women appear to be at higher risk than men of developing rash with nevirapine
The most common adverse effect is rash
HIV infection in combination with other antiretroviral drugs (maintenance dose following initial dose titration if no rash present) for nevirapine Nevirapine treatment can cause a skin rash
Patients 16 years and older
In contrast to findings in other studies, NNRTI-associated rashes in Ghanaians appear more common in patients with lower baseline CD4 counts
Maintenance dose: 120 to 150 mg/m2 orally twice a day
The most common Nevirapine
Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning
Nevirapine, used for the treatment of HIV infection, is associated with development of skin rash and liver toxicity
The most common side effect of nevirapine is skin rash