Sep 15, 2018 · Fenofibrate is a hypolipidemic drug with low water solubility [7] and poor bioavailability [8], with a relatively low melting point of 79–82 °C, which was first commercialized in France in the 1970 s
The pH of the microenvironment within the diluted formulations may not have drastic effect on the solubility of fenofibrate during equilibration or dispersion
3 μg/mL at 24 h
Fenofibrate is a poorly water soluble lipid-regulating drug used to control triglyceride and cholesterol levels in blood plasma
Go to: Indications Fenofibrate is FDA approved for the management and treatment of hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia
Solubility can be enhanced by particle size reduction and encapsulation using hydrophilic polymers
It is less commonly used compared
In this study, ASDs of poorly soluble fenofibrate, a drug with a low Tg, were formulated using hydroxy propyl methylcellulose acetate succinate (HPMCAS) via hot
The dissolution behavior of
Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM
Saturated solutions were prepared by adding the excess drug to the vehicles and shaking on the
However, due to its poor aqueous solubility, FNB has the problem of poor oral absorption followed by low bioavailability
It was observed that the enhancement in intrinsic dissolution rate was approximately 500-fold
The highest solubility observed was 447
SLS could solubilize most poorly soluble drugs and the solubility of fenofibrate was higher than those in TPGS solution
Fenofibrate is sparingly soluble in aqueous buffers
We do not recommend Fenofibric acid is a monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4- (4-chlorobenzoyl)phenoxy group at position 2
The results indicate that the impact of excipients on fenofibrate solubility is a complex interplay of media composition in combination with their physicochemical properties and concentration
Fenofibrate was chosen as a model drug based on previous studies [11,12,13] since it is non-ionic and therefore not directly influenced by media pH
These complexes were evaluated by dissolution studies, fourier transform infrared (FTIR Fenofibrate is a BCS Class-II drug having poor water solubility
Due to this, several different formulations of fenofibrate have been developed to increase the drug’s overall solubility
9 shows estimated activity coefficients from the experimental temperature interval to Tm M for form I in all investigated solvents
57 mg/mL in EtOH : Chemical Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate However, Fenofibrate treatment significantly decreased the body weight and increased the relative liver weight
5%)
that the solubility of Fenofibrate was higher in ethanol and pH 7
Objective: Fenofibrate, a hypolipidemic drug agent, exhibits poor water solubility and dissolution
Fenofibrate is a lipid lowering drug used in the treatment of hyperlipidemia and shows poor aqueous solubility
Solubility and permeability are the fundamental parameters controlling the rate and extent of drug absorption