A study of patients with rheumatic disease found that rapidity of steroid taper did not make a difference in HPA-axis recovery
25 mg; 0
Current guidelines do not
Patients receiving prolonged, high-dose corticosteroid treatment (16–25 mg of prednisolone per day or ≥4 mg dexamethasone daily for ≥4 weeks) are also at high risk
Stress dose is based on patient's current maintenance dose
It works on the immune system to help relieve swelling, redness, itching, and allergic
Dosage forms: oral
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Also, the lowest possible dose should be used
1-12 Dexamethasone has been the steroid most commonly used due to its minimal mineralocorticoid effect
Tapering of steroid dosing within 1 week of starting therapy and discontinuation within 2 weeks if possible was encouraged (Good Practice Point)
5 mg of Dexamethasone tablets, USP orally every 6 hours for 48 hours
One arm received 22 days of prednisone tapering over 9 days and the second group received 22 days of dexamethasone which was weaned over 9 days
Extensive fever workup was implemented but did not reveal a source of infection
If further steroid tapering is required, the patient should then be switched to a more intermediate acting steroid, such as prednisone, because long-acting corticosteroids like dexamethasone do Dexamethasone 27: Minimal Long: Anti-inflammatory and immunosuppressive, used especially when water retention is undesirable (e
Objectives: To develop expert consensus on OCS tapering among international experts
In the first large-scale clinical Patients received an initial intravenous bolus of 100 mg dexamethasone, followed by 3 days of 24 mg oral dexamethasone 4 times per day with tapering and cessation of dexamethasone on day 14 of treatment
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Tapering guidance: Continue IV methylprednisolone 2mg/kg/day for a total of 5 days then switch to oral prednisolone 1mg/kg/day x 3 days, then reduce to 60mg/day Prednisolone
Healthy optic nerves can tolerate IOP in the high 20s or low 30s for a few weeks without any measurable damage to structure or function
Steroids are the mainstay of treatment for giant cell arteritis (GCA), inflammatory orbital pseudotumor, Tolosa-Hunt syndrome (THS), optic neuritis, trochleitis, and ophthalmoplegic migraine
placebo B2 Meta-analysis of 7 RCTs N = 383 patients; mean age = 37 to 46 years Dexamethasone is a corticosteroid that's similar to a hormone that your body naturally makes, called cortisol
A reasonable approach could be a single dose of 10 mg dexamethasone, which will auto-taper itself off over a course of a couple days (obviating the need for any sort of steroid taper)